5-amino-2-benzyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

Base Information

Chemical Name:5-amino-2-benzyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile
CAS No.:1535168-76-3
Molecular Formula:C₁₅H₁₈N₄O
Molecular Weight:270.334
Hs Code.:

Synonyms:5-amino-2-benzyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

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Chemical Property of 5-amino-2-benzyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

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Technology Process of 5-amino-2-benzyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

There total 1 articles about 5-amino-2-benzyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 4369-00-0
(2,2,2-trimethoxyethyl)benzene

: 5098-14-6
2-aminomalononitrile p-toluenesulfonate

: 2854-16-2
1-Amino-2-methyl-propan-2-ol

: 1535168-76-3
5-amino-2-benzyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

Guidance literature:: 2-aminomalononitrile p-toluenesulfonate; With triethylamine; In tetrahydrofuran; at 25 ℃; for 0.5h;

(2,2,2-trimethoxyethyl)benzene; In tetrahydrofuran; for 3h; Reflux;

1-Amino-2-methyl-propan-2-ol; In tetrahydrofuran; at 25 ℃; for 15h;
DOI:10.1021/jm4004957

Reference yield: 70.0%

: 1535168-76-3
5-amino-2-benzyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

: 1535168-87-6
2-benzyl-1-(2-hydroxy-2-methylpropyl)-5-iodo-1H-imidazole-4-carbonitrile

Guidance literature:: With diiodomethane; isopentyl nitrite; In chloroform; at 80 ℃; for 0.5h;
DOI:10.1021/jm4004957

Reference yield:

: 1535168-76-3
5-amino-2-benzyl-1-(2-hydroxy-2-methylpropyl)-1H-imidazole-4-carbonitrile

: 1535168-98-9
C₂₃H₂₄N₄O₃

Guidance literature:: Multi-step reaction with 2 steps

1: isopentyl nitrite; diiodomethane / chloroform / 0.5 h / 80 °C

2: palladium(II) catalyst / water / 3 h / 25 - 100 °C / Inert atmosphere; Alkaline conditions

With diiodomethane; isopentyl nitrite; In chloroform; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm4004957