(3R,3aS,9bR)-diethyl 3a-benzamido-3-(naphthalen-2-yl)-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate

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Chemical Name:(3R,3aS,9bR)-diethyl 3a-benzamido-3-(naphthalen-2-yl)-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate
CAS No.:1562376-82-2
Molecular Formula:C₃₄H₃₀N₂O₇
Molecular Weight:578.621
Hs Code.:

Synonyms:(3R,3aS,9bR)-diethyl 3a-benzamido-3-(naphthalen-2-yl)-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate

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Chemical Property of (3R,3aS,9bR)-diethyl 3a-benzamido-3-(naphthalen-2-yl)-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate

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Technology Process of (3R,3aS,9bR)-diethyl 3a-benzamido-3-(naphthalen-2-yl)-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate

There total 3 articles about (3R,3aS,9bR)-diethyl 3a-benzamido-3-(naphthalen-2-yl)-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 147093-03-6,66404-27-1
4-(2-naphthylidene)-2-phenyl-5(4H)oxazolone

: (E)-diethyl 2-((2-hydroxybenzylidene)amino)malonate

: 1562376-82-2
(3R,3aS,9bR)-diethyl 3a-benzamido-3-(naphthalen-2-yl)-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate

Guidance literature:: With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; In dichloromethane; at 20 ℃; for 2h; enantioselective reaction;
DOI:10.1039/c3cc49504c

Reference yield:

: 13433-00-6
diethyl aminomalonate hydrochloride

: 1562376-82-2
(3R,3aS,9bR)-diethyl 3a-benzamido-3-(naphthalen-2-yl)-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / water / 0.25 h

2: magnesium sulfate / dichloromethane / 48 h / 20 °C

3: 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea / dichloromethane / 2 h / 20 °C

With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; sodium hydrogencarbonate; magnesium sulfate; In dichloromethane; water;
DOI:10.1039/c3cc49504c

Reference yield:

: 6829-40-9
aminomalonic acid diethyl ester

: 1562376-82-2
(3R,3aS,9bR)-diethyl 3a-benzamido-3-(naphthalen-2-yl)-4-oxo-1,3a,4,9b-tetrahydrochromeno[4,3-b]pyrrole-2,2(3H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: magnesium sulfate / dichloromethane / 48 h / 20 °C

2: 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea / dichloromethane / 2 h / 20 °C

With 1-(3,5-bis(trifluoromethyl)phenyl)-3-((S)-(6-methoxyquinolin-4-yl)((1S,2S,4S,5R)-5-vinylquinuclidin-2-yl)methyl)thiourea; magnesium sulfate; In dichloromethane;
DOI:10.1039/c3cc49504c