5-nitro-2-(N-phenylaminocarbonylmethylthio)-3-cyanopyridine

Base Information

• Chemical Name: 5-nitro-2-(N-phenylaminocarbonylmethylthio)-3-cyanopyridine
• CAS No.: 293735-69-0
• Molecular Formula: C₁₄H₁₀N₄O₃S
• Molecular Weight: 314.324
• Mol file: 293735-69-0.mol

Synonyms:5-nitro-2-(N-phenylaminocarbonylmethylthio)-3-cyanopyridine

Chemical Property of 5-nitro-2-(N-phenylaminocarbonylmethylthio)-3-cyanopyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 5-nitro-2-(N-phenylaminocarbonylmethylthio)-3-cyanopyridine

There total 1 articles about 5-nitro-2-(N-phenylaminocarbonylmethylthio)-3-cyanopyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-chloro-5-nitropyridine-3-carbonitrile (31309-08-7) + 2-mercapto-N-phenylacetamide (4822-44-0) → 5-nitro-2-(N-phenylaminocarbonylmethylthio)-3-cyanopyridine (293735-69-0)

Guidance literature:

With sodium acetate; In ethanol; at 20 ℃; for 1h;

DOI:10.1007/BF02464367

Reference yield: 97.0%

5-nitro-2-(N-phenylaminocarbonylmethylthio)-3-cyanopyridine (293735-69-0) → 3-amino-5-nitro-2-(N-phenylaminocarbonyl)thieno[2,3-b]pyridine (293735-70-3)

Guidance literature:

sodium ethanolate; In ethanol; Heating;

DOI:10.1007/BF02464367

Reference yield:

5-nitro-2-(N-phenylaminocarbonylmethylthio)-3-cyanopyridine (293735-69-0) → 8-nitro-3-phenylpyrido[3',2':4,5]thieno[3.2-d]pyrimidin-4(3H)-one (293735-80-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / sodium ethylate / ethanol / Heating

2: 80 percent / acetic anhydride / 1.5 h / Heating

sodium ethanolate; In ethanol; acetic anhydride; 1: Cyclization / 2: Cycloaddition;

DOI:10.1007/BF02464367

upstream raw materials:

2-chloro-5-nitropyridine-3-carbonitrile

2-mercapto-N-phenylacetamide

Downstream raw materials:

3-amino-5-nitro-2-(N-phenylaminocarbonyl)thieno[2,3-b]pyridine

8-nitro-3-phenylpyrido[3',2':4,5]thieno[3.2-d]pyrimidin-4(3H)-one