[4-Chloro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-acetic acid ethyl ester

Base Information

Chemical Name:[4-Chloro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-acetic acid ethyl ester
CAS No.:770718-99-5
Molecular Formula:C₁₈H₁₃ClF₃NO₃
Molecular Weight:383.754
Hs Code.:

Synonyms:[4-Chloro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-acetic acid ethyl ester

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Chemical Property of [4-Chloro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-acetic acid ethyl ester

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Technology Process of [4-Chloro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-acetic acid ethyl ester

There total 4 articles about [4-Chloro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1007572-04-4
C₁₇H₁₃BrClF₃O₃

: 557-21-1
dicyanozinc

: 770718-99-5
[4-Chloro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-acetic acid ethyl ester

Guidance literature:: tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 4h;

Reference yield: 87.0%

: 1007572-04-4
C₁₇H₁₃BrClF₃O₃

: 770718-99-5
[4-Chloro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-acetic acid ethyl ester

Guidance literature:: C₁₇H₁₃BrClF₃O₃; With dicyanozinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 4h;

With ammonia; In DMF (N,N-dimethyl-formamide); water; at 20 ℃;

Reference yield:

Zn(CN)2: Zn(CN)2

: reverse transcriptase

LiOH monohydrate: LiOH monohydrate

: 770718-98-4
3-Bromo-5-difluoromethyl-phenol

: 770718-97-3
3-bromo-5-formyl-phenyl acetate

: 2-DAST

: ethyl 2,3-difluoro-4-nitro-phenyl acetate

: 770718-99-5
[4-Chloro-3-(3-cyano-5-difluoromethyl-phenoxy)-2-fluoro-phenyl]-acetic acid ethyl ester

Guidance literature:: With hydrogenchloride; ammonium hydroxide; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate; N,N-dimethyl-formamide;