5-[2-(3-hydroxyprop-1-ynyl)-4,4-dimethyl-6-oxocyclohex-1-enyl]pent-2-ynyl acetate

Base Information

Chemical Name:5-[2-(3-hydroxyprop-1-ynyl)-4,4-dimethyl-6-oxocyclohex-1-enyl]pent-2-ynyl acetate
CAS No.:1418184-09-4
Molecular Formula:C₁₈H₂₂O₄
Molecular Weight:302.37
Hs Code.:

Synonyms:5-[2-(3-hydroxyprop-1-ynyl)-4,4-dimethyl-6-oxocyclohex-1-enyl]pent-2-ynyl acetate

Suppliers and Price of 5-[2-(3-hydroxyprop-1-ynyl)-4,4-dimethyl-6-oxocyclohex-1-enyl]pent-2-ynyl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-[2-(3-hydroxyprop-1-ynyl)-4,4-dimethyl-6-oxocyclohex-1-enyl]pent-2-ynyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-[2-(3-hydroxyprop-1-ynyl)-4,4-dimethyl-6-oxocyclohex-1-enyl]pent-2-ynyl acetate

There total 5 articles about 5-[2-(3-hydroxyprop-1-ynyl)-4,4-dimethyl-6-oxocyclohex-1-enyl]pent-2-ynyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1418184-15-2
5-[6-hydroxy-4,4-dimethyl-2-(trifluoromethylsulfonyloxy)cyclohex-1-enyl]pent-2-ynyl acetate

: 107-19-7
propargyl alcohol

: 1418184-09-4
5-[2-(3-hydroxyprop-1-ynyl)-4,4-dimethyl-6-oxocyclohex-1-enyl]pent-2-ynyl acetate

Guidance literature:: 5-[6-hydroxy-4,4-dimethyl-2-(trifluoromethylsulfonyloxy)cyclohex-1-enyl]pent-2-ynyl acetate; With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In dimethyl sulfoxide; at 20 ℃; for 5.5h; Inert atmosphere;

propargyl alcohol; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In dimethyl sulfoxide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.tet.2012.12.014

Reference yield:

: 1418184-10-7
2-allyl-3-hydroxy-5,5-dimethylcyclohex-1-enyl trifluoromethanesulfonate

: 1418184-09-4
5-[2-(3-hydroxyprop-1-ynyl)-4,4-dimethyl-6-oxocyclohex-1-enyl]pent-2-ynyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

1.2: 1.5 h / 0 - 20 °C / Inert atmosphere

2.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 3.5 h / 20 °C / Inert atmosphere

2.2: Ohira-Bestmann reagent / 20 °C / Inert atmosphere

3.1: ethylmagnesium bromide / tetrahydrofuran / 2 h / 0 - 50 °C / Inert atmosphere

3.2: 20 °C / Inert atmosphere

4.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

5.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

6.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 5.5 h / 20 °C / Inert atmosphere

6.2: 2 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; ethylmagnesium bromide; tetrabutyl ammonium fluoride; acetic acid; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2012.12.014

Reference yield:

: 1418184-11-8
3-(tert-butyldimethylsilyloxy)-2-(3-hydroxypropyl)-5,5-dimethylcyclohex-1-enyl trifluoromethanesulfonate

: 1418184-09-4
5-[2-(3-hydroxyprop-1-ynyl)-4,4-dimethyl-6-oxocyclohex-1-enyl]pent-2-ynyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 3.5 h / 20 °C / Inert atmosphere

1.2: Ohira-Bestmann reagent / 20 °C / Inert atmosphere

2.1: ethylmagnesium bromide / tetrahydrofuran / 2 h / 0 - 50 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: dmap; triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

5.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 5.5 h / 20 °C / Inert atmosphere

5.2: 2 h / 20 °C / Inert atmosphere

With dmap; ethylmagnesium bromide; tetrabutyl ammonium fluoride; acetic acid; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/j.tet.2012.12.014