Sgd 28-74

Base Information

• Chemical Name: Sgd 28-74
• CAS No.: 57081-51-3
• Molecular Formula: C18H19ClO3
• Molecular Weight: 318.79
• Mol file: 57081-51-3.mol

Synonyms:ethyl 2-[2-[(4-chlorophenyl)methyl]phenoxy]propanoate;Ethyl (+-)-2-(2-((4-chlorophenyl)methyl)phenoxy)propanoate;Propanoic acid, 2-(2-((4-chlorophenyl)methyl)phenoxy)-, ethyl ester, (+-)-;

Chemical Property of Sgd 28-74

Chemical Property:

• Boiling Point: 407.2±30.0 °C(Predicted)
• PSA: 35.53000
• Density: 1.160±0.06 g/cm3(Predicted)
• LogP: 4.26120

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Sgd 28-74

There total 1 articles about Sgd 28-74 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-2'-hydroxydiphenylmethane (31480-68-9) + Ethyl 2-bromopropionate (535-11-5,41978-69-2) → 2-[2-(4-Chloro-benzyl)-phenoxy]-propionic acid ethyl ester (57081-51-3,71565-50-9)

Guidance literature:

Multistep reaction; (i) K₂CO₃, xylene, (ii) /BRN= 773920/;

Reference yield:

2-[2-(4-Chloro-benzyl)-phenoxy]-propionic acid ethyl ester (57081-51-3,71565-50-9) → Sodium; 2-[2-(4-chloro-benzyl)-phenoxy]-3-(4-chloro-phenyl)-2-methyl-propionate

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) N-isopropylcyclohexylamine, n-BuLi / 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, from -70 deg C to RT, overnight

2: 5N aq. NaOH / ethanol / 4 h / 60 °C

With sodium hydroxide; n-butyllithium; N-cyclohexylisopropylamine; In ethanol;

DOI:10.1021/jm950364f

Reference yield:

2-[2-(4-Chloro-benzyl)-phenoxy]-propionic acid ethyl ester (57081-51-3,71565-50-9) → 2-[2-(4-Chloro-benzyl)-phenoxy]-3-(4-chloro-phenyl)-2-methyl-propionic acid ethyl ester (1026979-44-1)

Guidance literature:

With n-butyllithium; N-cyclohexylisopropylamine; Multistep reaction; 1.) THF, hexane, -78 deg C, 20 min, 2.) THF, hexane, from -70 deg C to RT, overnight;

DOI:10.1021/jm950364f

upstream raw materials:

4-chloro-2'-hydroxydiphenylmethane

Ethyl 2-bromopropionate

Downstream raw materials:

2-[2-(4-Chloro-benzyl)-phenoxy]-3-(4-chloro-phenyl)-2-methyl-propionic acid ethyl ester