(S)-N-tert-butoxycarbonyl-2-[(S)-α-(2-(carbomethoxy)phenoxy)benzyl]morpholine

Base Information

• Chemical Name: (S)-N-tert-butoxycarbonyl-2-[(S)-α-(2-(carbomethoxy)phenoxy)benzyl]morpholine
• CAS No.: 1016544-96-9
• Molecular Formula: C₂₄H₂₉NO₆
• Molecular Weight: 427.497

Synonyms:(S)-N-tert-butoxycarbonyl-2-[(S)-α-(2-(carbomethoxy)phenoxy)benzyl]morpholine

Chemical Property of (S)-N-tert-butoxycarbonyl-2-[(S)-α-(2-(carbomethoxy)phenoxy)benzyl]morpholine

Chemical Property:

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Technology Process of (S)-N-tert-butoxycarbonyl-2-[(S)-α-(2-(carbomethoxy)phenoxy)benzyl]morpholine

There total 1 articles about (S)-N-tert-butoxycarbonyl-2-[(S)-α-(2-(carbomethoxy)phenoxy)benzyl]morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(+)-(2S,3R)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester (847805-33-8) + methyl salicylate (119-36-8,8024-54-2) → (S)-N-tert-butoxycarbonyl-2-[(S)-α-(2-(carbomethoxy)phenoxy)benzyl]morpholine (1016544-96-9)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 24h;

DOI:10.1016/j.bmc.2007.10.025

Reference yield: 67.0%

(S)-N-tert-butoxycarbonyl-2-[(S)-α-(2-(carbomethoxy)phenoxy)benzyl]morpholine (1016544-96-9) → 2-{(S)-[(S)-N-(tert-butoxycarbonyl)morpholin-2-yl](phenyl)methoxy}benzoic acid (1016545-04-2)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 110 ℃;

DOI:10.1016/j.bmc.2007.10.025

Reference yield: 60.0%

(S)-N-tert-butoxycarbonyl-2-[(S)-α-(2-(carbomethoxy)phenoxy)benzyl]morpholine (1016544-96-9) → C19H21NO4 (1016545-13-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1016/j.bmc.2007.10.025

upstream raw materials:

(+)-(2S,3R)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester

methyl salicylate

Downstream raw materials:

2-{(S)-[(S)-N-(tert-butoxycarbonyl)morpholin-2-yl](phenyl)methoxy}benzoic acid

C₁₉H₂₁NO₄

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