(2S,4S)-1-(2,2-diphenylacetyl)-4-(methyl(4-methylpent-2-yn-1-yl)amino)piperidine-2-carboxylic acid

Base Information

Chemical Name:(2S,4S)-1-(2,2-diphenylacetyl)-4-(methyl(4-methylpent-2-yn-1-yl)amino)piperidine-2-carboxylic acid
CAS No.:1448667-79-5
Molecular Formula:C₂₇H₃₂N₂O₃
Molecular Weight:432.563
Hs Code.:

Synonyms:(2S,4S)-1-(2,2-diphenylacetyl)-4-(methyl(4-methylpent-2-yn-1-yl)amino)piperidine-2-carboxylic acid

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Chemical Property of (2S,4S)-1-(2,2-diphenylacetyl)-4-(methyl(4-methylpent-2-yn-1-yl)amino)piperidine-2-carboxylic acid

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Technology Process of (2S,4S)-1-(2,2-diphenylacetyl)-4-(methyl(4-methylpent-2-yn-1-yl)amino)piperidine-2-carboxylic acid

There total 10 articles about (2S,4S)-1-(2,2-diphenylacetyl)-4-(methyl(4-methylpent-2-yn-1-yl)amino)piperidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1448668-22-1
C₂₈H₃₄N₂O₃

: 1448667-79-5
(2S,4S)-1-(2,2-diphenylacetyl)-4-(methyl(4-methylpent-2-yn-1-yl)amino)piperidine-2-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 598-23-2
3-methyl-but-1-yne

: 1448667-79-5
(2S,4S)-1-(2,2-diphenylacetyl)-4-(methyl(4-methylpent-2-yn-1-yl)amino)piperidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -65 °C / Inert atmosphere

1.2: -65 - 20 °C

2.1: dichloromethane / 1 h / 0 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 40 °C / Sealed tube

4.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

With n-butyllithium; lithium hydroxide monohydrate; water; caesium carbonate; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 15787-92-5
4-methyl-2-pentyn-1-ol

: 1448667-79-5
(2S,4S)-1-(2,2-diphenylacetyl)-4-(methyl(4-methylpent-2-yn-1-yl)amino)piperidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 1 h / 0 °C / Inert atmosphere

2: caesium carbonate / N,N-dimethyl-formamide / 40 °C / Sealed tube

3: lithium hydroxide monohydrate; water / tetrahydrofuran / 20 °C

With lithium hydroxide monohydrate; water; caesium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;