Technology Process of N-[4-[6-tert-butyl-8-(5-fluoro-2-methoxy-3-pyridyl)-5-methoxy-3-quinolyl]phenyl]methanesulfonamide
There total 6 articles about N-[4-[6-tert-butyl-8-(5-fluoro-2-methoxy-3-pyridyl)-5-methoxy-3-quinolyl]phenyl]methanesulfonamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(triphenylphosphine) palladium(0); sodium carbonate;
In
methanol; dichloromethane;
at 115 ℃;
for 1h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1021/jm401329s
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: potassium hydroxide; water / ethanol / 15 h / Reflux; Inert atmosphere
2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere
3.1: bromine; acetic acid / 0.25 h / 20 °C / Inert atmosphere
3.2: 4 h / 100 °C / Inert atmosphere
4.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / methanol; toluene / 1 h / 120 °C / Inert atmosphere; Sealed tube; Microwave irradiation
5.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / methanol; dichloromethane / 1 h / 115 °C / Inert atmosphere; Microwave irradiation
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); water; bromine; sodium carbonate; acetic acid; potassium hydroxide;
In
methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm401329s
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: diphenylphosphoranyl azide; triethylamine / tetrahydrofuran / 23 h / Reflux; Inert atmosphere
2.1: potassium hydroxide; water / ethanol / 15 h / Reflux; Inert atmosphere
3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere
4.1: bromine; acetic acid / 0.25 h / 20 °C / Inert atmosphere
4.2: 4 h / 100 °C / Inert atmosphere
5.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / methanol; toluene / 1 h / 120 °C / Inert atmosphere; Sealed tube; Microwave irradiation
6.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / methanol; dichloromethane / 1 h / 115 °C / Inert atmosphere; Microwave irradiation
With
N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); diphenylphosphoranyl azide; water; bromine; sodium carbonate; acetic acid; triethylamine; potassium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
1.1: |Curtius Rearrangement;
DOI:10.1021/jm401329s
