ethyl 4-(N-tert-butoxycarbonyl)amino-3-formylbenzoate

Base Information

Chemical Name:ethyl 4-(N-tert-butoxycarbonyl)amino-3-formylbenzoate
CAS No.:260559-81-7
Molecular Formula:C₁₅H₁₉NO₅
Molecular Weight:293.32
Hs Code.:

Synonyms:ethyl 4-(N-tert-butoxycarbonyl)amino-3-formylbenzoate

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Chemical Property of ethyl 4-(N-tert-butoxycarbonyl)amino-3-formylbenzoate

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Technology Process of ethyl 4-(N-tert-butoxycarbonyl)amino-3-formylbenzoate

There total 5 articles about ethyl 4-(N-tert-butoxycarbonyl)amino-3-formylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 260559-80-6
ethyl 4-(N-tert-butoxycarbonyl)amino-3-ethenylbenzoate

: 260559-81-7
ethyl 4-(N-tert-butoxycarbonyl)amino-3-formylbenzoate

Guidance literature:: ethyl 4-(N-tert-butoxycarbonyl)amino-3-ethenylbenzoate; With ozone; In dichloromethane; at -78 ℃; for 0.5h;

With 2,3-dimercapto-succinic acid; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jo990843c

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 260559-81-7
ethyl 4-(N-tert-butoxycarbonyl)amino-3-formylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent

2.1: 100 percent / Br₂; sodium acetate / acetic acid / 41 h

3.1: 85 percent / 2,6-di-tert-butyl-4-methylphenol; Pd(PPh₃)4 / toluene / 24 h / Heating

4.1: O₃ / CH₂Cl₂ / 0.5 h / -78 °C

4.2: 78 percent / DMS / -78 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; bromine; sodium acetate; ozone; In dichloromethane; acetic acid; toluene; 1.1: Acylation / 2.1: Bromination / 3.1: Alkylation / 4.1: ozonolysis / 4.2: Reduction;
DOI:10.1021/jo990843c

Reference yield:

: 110969-44-3
4-tert-butyloxycarbonylaminobenzoic acid ethyl ester

: 260559-81-7
ethyl 4-(N-tert-butoxycarbonyl)amino-3-formylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / Br₂; sodium acetate / acetic acid / 41 h

2.1: 85 percent / 2,6-di-tert-butyl-4-methylphenol; Pd(PPh₃)4 / toluene / 24 h / Heating

3.1: O₃ / CH₂Cl₂ / 0.5 h / -78 °C

3.2: 78 percent / DMS / -78 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 2,6-di-tert-butyl-4-methyl-phenol; bromine; sodium acetate; ozone; In dichloromethane; acetic acid; toluene; 1.1: Bromination / 2.1: Alkylation / 3.1: ozonolysis / 3.2: Reduction;
DOI:10.1021/jo990843c