N-[(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methylene](phenyl)methanamine

Base Information

• Chemical Name: N-[(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methylene](phenyl)methanamine
• CAS No.: 371171-27-6
• Molecular Formula: C₂₁H₁₇N₃S
• Molecular Weight: 343.452
• Mol file: 371171-27-6.mol

Synonyms:N-[(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methylene](phenyl)methanamine

Chemical Property of N-[(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methylene](phenyl)methanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methylene](phenyl)methanamine

There total 4 articles about N-[(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methylene](phenyl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

benzylamine (100-46-9) + 1-phenyl-3-thiophen-2-yl-1H-pyrazole-4-carbaldehyde (210825-11-9) → N-[(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methylene](phenyl)methanamine (371171-27-6)

Guidance literature:

With acetic acid; In benzene; for 2h; Heating;

DOI:10.1023/A:1012494221885

Reference yield:

1-[1-(thiophen-2-yl)ethylidene]-2-phenylhydrazine (55968-17-7) → N-[(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methylene](phenyl)methanamine (371171-27-6)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate / 60 °C

2: dichloromethane / 20 °C / Molecular sieve

With trichlorophosphate; In dichloromethane;

DOI:10.1016/j.tet.2019.07.001

Reference yield:

2-Acetylthiophene (88-15-3,97511-16-5) → N-[(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-4-yl)methylene](phenyl)methanamine (371171-27-6)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate / ethanol / Reflux

2: trichlorophosphate / 60 °C

3: dichloromethane / 20 °C / Molecular sieve

With sodium acetate; trichlorophosphate; In ethanol; dichloromethane;

DOI:10.1016/j.tet.2019.07.001

upstream raw materials:

benzylamine

1-phenyl-3-thiophen-2-yl-1H-pyrazole-4-carbaldehyde

1-[1-(thiophen-2-yl)ethylidene]-2-phenylhydrazine

2-Acetylthiophene

Downstream raw materials:

[benzylamino-(1-phenyl-3-thiophen-2-yl-1H-pyrazol-4-yl)-methyl]-phosphonic acid diethyl ester