ethyl 1-(4-fluorophenyl)-4-(N-methoxycarbonyl-N-cyclopropylamino)cyclohexanecarboxylate

Base Information

Chemical Name:ethyl 1-(4-fluorophenyl)-4-(N-methoxycarbonyl-N-cyclopropylamino)cyclohexanecarboxylate
CAS No.:1082739-47-6
Molecular Formula:C₂₀H₂₆FNO₄
Molecular Weight:363.429
Hs Code.:

Synonyms:ethyl 1-(4-fluorophenyl)-4-(N-methoxycarbonyl-N-cyclopropylamino)cyclohexanecarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 1-(4-fluorophenyl)-4-(N-methoxycarbonyl-N-cyclopropylamino)cyclohexanecarboxylate

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Technology Process of ethyl 1-(4-fluorophenyl)-4-(N-methoxycarbonyl-N-cyclopropylamino)cyclohexanecarboxylate

There total 1 articles about ethyl 1-(4-fluorophenyl)-4-(N-methoxycarbonyl-N-cyclopropylamino)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1082739-34-1
ethyl 4-(N-methoxycarbonyl-N-cyclopropyl)-aminocyclohexanecarboxylate

: 460-00-4
1-Bromo-4-fluorobenzene

: 1082739-47-6
ethyl 1-(4-fluorophenyl)-4-(N-methoxycarbonyl-N-cyclopropylamino)cyclohexanecarboxylate

Guidance literature:: ethyl 4-(N-methoxycarbonyl-N-cyclopropyl)-aminocyclohexanecarboxylate; With lithium diisopropyl amide; In hexane; toluene; at 0 - 23 ℃; Inert atmosphere;

1-Bromo-4-fluorobenzene; With di-μ-bromobis(tri-tert-butylphosphino)dipalladium(I); In hexane; toluene; at 23 ℃; for 16h; diastereoselective reaction; Inert atmosphere;
DOI:10.1021/ol8021758