2,4-bis(β-chloroethyl)-6,7-bis(β-methoxycarbonylethyl)-1,3,5-trimethylporphyrin

Base Information

Chemical Name:2,4-bis(β-chloroethyl)-6,7-bis(β-methoxycarbonylethyl)-1,3,5-trimethylporphyrin
CAS No.:121211-58-3
Molecular Formula:C₃₅H₃₈Cl₂N₄O₄
Molecular Weight:649.617
Hs Code.:

Synonyms:2,4-bis(β-chloroethyl)-6,7-bis(β-methoxycarbonylethyl)-1,3,5-trimethylporphyrin

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Chemical Property of 2,4-bis(β-chloroethyl)-6,7-bis(β-methoxycarbonylethyl)-1,3,5-trimethylporphyrin

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Technology Process of 2,4-bis(β-chloroethyl)-6,7-bis(β-methoxycarbonylethyl)-1,3,5-trimethylporphyrin

There total 1 articles about 2,4-bis(β-chloroethyl)-6,7-bis(β-methoxycarbonylethyl)-1,3,5-trimethylporphyrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7126-57-0
ethyl 4-formylpyrrole-2-carboxylate

: 121211-58-3
2,4-bis(β-chloroethyl)-6,7-bis(β-methoxycarbonylethyl)-1,3,5-trimethylporphyrin

Guidance literature:: Multi-step reaction with 13 steps

1: 93 percent / piperidine / pyridine / 1.) 90 deg C, 6 h; 2.) 130 deg C, 3 h

2: 98 percent / hydrogen / 10 percent Pd on charcoal / ethanol / 2 h / 2585.7 Torr

3: 98 percent / 10 percent sodium hydroxide / ethanol / 100 °C

4: 95 percent / triethylamine / dimethylformamide / 48 h / 20 °C

5: 78 percent / 5 percent sulfuric acid / methanol / 18 h / 20 °C

6: 1.) phosphorous oxychloride / 1.) 20 deg C, 1 h; 2.) 1,2-dichloroethane, 85 deg C, 4 h

7: 86 percent / sodium borohydride / methanol; CH₂Cl₂ / 0.33 h / 20 °C

8: 70 percent / p-toluenesulfonic acid / CH₂Cl₂ / 4 h / 40 °C

9: 92 percent / hydrogen / 10 percent Pd on charcoal / ethanol / 4 h / 2585.7 Torr

10: 73 percent / triethylamine / methanol / 0.1 h / 185 °C / 0.1 Torr

11: 60 percent / 33 percent hydrobromic acid / methanol; acetic acid / 1 h / 20 °C / in the dark

12: 1.) trifluoroacetic acid; 2.) 33 percent hydrobromic acid / 1.) 20 deg C, 10 min; 2.) methanol, acetic acid, 20 deg C, 2.5 h

With piperidine; sodium hydroxide; sodium tetrahydroborate; sulfuric acid; hydrogen bromide; hydrogen; toluene-4-sulfonic acid; triethylamine; trifluoroacetic acid; trichlorophosphate; palladium on activated charcoal; In pyridine; methanol; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)89134-1

Reference yield:

: 121211-58-3
2,4-bis(2-chloroethyl)-6,7-bis<2-(methoxycarbonyl)ethyl>-1,3,5-trimethylporphyrin

: 121211-62-9
8-(hydroxymethyl)-6,7-bis<2-(methoxycarbonyl)ethyl>-1,3,5-trimethyl-2,4-divinylporphyrin

Guidance literature:: Multi-step reaction with 3 steps

2: 95 percent / sodium borohydride / CH₂Cl₂; methanol / 0.17 h / 0 °C

3: 90 percent / 1,5-diazabicyclo<5.4.0>undecene-5 (DBU) / dimethylformamide / 1.5 h / 75 °C

With sodium tetrahydroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00275a009