C₂₇H₃₉NO₂SSi

Base Information

• Chemical Name: C₂₇H₃₉NO₂SSi
• CAS No.: 1447825-91-3
• Molecular Formula: C₂₇H₃₉NO₂SSi
• Molecular Weight: 469.764
• Mol file: 1447825-91-3.mol

Synonyms:C₂₇H₃₉NO₂SSi

Chemical Property of C₂₇H₃₉NO₂SSi

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₃₉NO₂SSi

There total 8 articles about C₂₇H₃₉NO₂SSi which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

C23H30O2Si (1447825-75-3) + (S)-2-methylpropane-2-sulfinamide (343338-28-3) → C27H39NO2SSi (1447825-91-3)

Guidance literature:

With copper(II) sulfate; In dichloromethane; at 20 ℃; for 22h; diastereoselective reaction;

DOI:10.1021/jm400542h

Reference yield:

(1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane (251444-03-8) → C27H39NO2SSi (1447825-91-3)

Guidance literature:

Multi-step reaction with 8 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

1.2: 0.33 h / 0 °C

2.1: water; hydrogenchloride / tetrahydrofuran / 1 h / 0 °C

3.1: 2-methyl-but-2-ene; sodium dihydrogenphosphate dihydrate; sodium chlorite / tert-butyl alcohol; water / 0.67 h / 20 °C

4.1: triethylamine / dichloromethane / 1 h / 0 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C

5.2: 1 h / -78 °C

6.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

6.2: 24 h / -78 °C

7.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.33 h / -78 °C

7.2: 1 h / 20 °C

8.1: copper(II) sulfate / dichloromethane / 22 h / 20 °C

With hydrogenchloride; sodium chlorite; n-butyllithium; sodium dihydrogenphosphate dihydrate; 2-methyl-but-2-ene; water; sodium hexamethyldisilazane; diisobutylaluminium hydride; copper(II) sulfate; triethylamine; In tetrahydrofuran; hexane; dichloromethane; water; toluene; tert-butyl alcohol; 1.1: |Wittig Olefination;

DOI:10.1021/jm400542h

Reference yield:

C32H37NO4Si (1447825-66-2) → C27H39NO2SSi (1447825-91-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: 24 h / -78 °C

2.1: diisobutylaluminium hydride / dichloromethane; toluene / 0.33 h / -78 °C

2.2: 1 h / 20 °C

3.1: copper(II) sulfate / dichloromethane / 22 h / 20 °C

With sodium hexamethyldisilazane; diisobutylaluminium hydride; copper(II) sulfate; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1021/jm400542h

upstream raw materials:

(1R,2S)-2-(tert-butyldiphenylsilyloxy)methyl-1-formylcyclopropane

C₃₂H₃₇NO₄Si

C₃₃H₃₉NO₄Si

C₂₂H₂₈O₃Si

Downstream raw materials:

C₂₅H₃₇N₃O₄

C₃₄H₄₀N₂O₄

C₃₃H₄₃N₃O₆

C₃₀H₃₃NO₃