4-amino-N-{[4-(4-carboxybenzyl)-2-morpholinyl]methyl}-5-chloro-2-ethoxybenzamide

Base Information

Chemical Name:4-amino-N-{[4-(4-carboxybenzyl)-2-morpholinyl]methyl}-5-chloro-2-ethoxybenzamide
CAS No.:131322-35-5
Molecular Formula:C₂₂H₂₆ClN₃O₅
Molecular Weight:447.919
Hs Code.:

Synonyms:4-amino-N-{[4-(4-carboxybenzyl)-2-morpholinyl]methyl}-5-chloro-2-ethoxybenzamide

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Chemical Property of 4-amino-N-{[4-(4-carboxybenzyl)-2-morpholinyl]methyl}-5-chloro-2-ethoxybenzamide

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Technology Process of 4-amino-N-{[4-(4-carboxybenzyl)-2-morpholinyl]methyl}-5-chloro-2-ethoxybenzamide

There total 3 articles about 4-amino-N-{[4-(4-carboxybenzyl)-2-morpholinyl]methyl}-5-chloro-2-ethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 131322-30-0
4-{2-[(4-Amino-5-chloro-2-ethoxy-benzoylamino)-methyl]-morpholin-4-ylmethyl}-benzoic acid methyl ester

: 131322-35-5
4-amino-N-{[4-(4-carboxybenzyl)-2-morpholinyl]methyl}-5-chloro-2-ethoxybenzamide

Guidance literature:: With sodium hydroxide; water; In ethanol; for 2h; Heating;
DOI:10.1021/jm00106a023

Reference yield:

: 59-06-3
methyl 4-acetamido-2-ethoxybenzoate

: 131322-35-5
4-amino-N-{[4-(4-carboxybenzyl)-2-morpholinyl]methyl}-5-chloro-2-ethoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / N-chlorosuccinimide (NCS) / dimethylformamide / 2 h / 70 °C

2: 99 percent / NaOH, H₂O / ethanol / 5 h / Heating

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

4: 93 percent / NaOH, H₂O / ethanol / 2 h / Heating

With sodium hydroxide; N-chloro-succinimide; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00106a023

Reference yield:

: 108282-38-8
4-amino-5-chloro-2-ethoxybenzoic acid

: 131322-35-5
4-amino-N-{[4-(4-carboxybenzyl)-2-morpholinyl]methyl}-5-chloro-2-ethoxybenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

2: 93 percent / NaOH, H₂O / ethanol / 2 h / Heating

With sodium hydroxide; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane;
DOI:10.1021/jm00106a023