5,5-dimethyl-3-phenyl-6-(phenylethynyl)-5,6-dihydro-4H-1,2,4-oxadiazin-6-ol

Base Information

Chemical Name:5,5-dimethyl-3-phenyl-6-(phenylethynyl)-5,6-dihydro-4H-1,2,4-oxadiazin-6-ol
CAS No.:1260435-58-2
Molecular Formula:C₁₉H₁₈N₂O₂
Molecular Weight:306.364
Hs Code.:

Synonyms:5,5-dimethyl-3-phenyl-6-(phenylethynyl)-5,6-dihydro-4H-1,2,4-oxadiazin-6-ol

Suppliers and Price of 5,5-dimethyl-3-phenyl-6-(phenylethynyl)-5,6-dihydro-4H-1,2,4-oxadiazin-6-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5,5-dimethyl-3-phenyl-6-(phenylethynyl)-5,6-dihydro-4H-1,2,4-oxadiazin-6-ol

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5,5-dimethyl-3-phenyl-6-(phenylethynyl)-5,6-dihydro-4H-1,2,4-oxadiazin-6-ol

There total 5 articles about 5,5-dimethyl-3-phenyl-6-(phenylethynyl)-5,6-dihydro-4H-1,2,4-oxadiazin-6-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260435-49-1
5-fluoro-4,4-dimethyl-2-phenyl-5-(phenylethynyl)-4,5-dihydrooxazole

: 1260435-58-2
5,5-dimethyl-3-phenyl-6-(phenylethynyl)-5,6-dihydro-4H-1,2,4-oxadiazin-6-ol

Guidance literature:: With hydroxylamine hydrochloride; In methanol; at 25 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol102454e

Reference yield:

: 1260435-39-9
N-(2-methyl-3-oxo-5-phenylpent-4-yn-2-yl)benzamide

: 1260435-58-2
5,5-dimethyl-3-phenyl-6-(phenylethynyl)-5,6-dihydro-4H-1,2,4-oxadiazin-6-ol

Guidance literature:: Multi-step reaction with 2 steps

1: diethylamino-sulfur trifluoride / dichloromethane / 0.5 h / -10 - 20 °C / Inert atmosphere

2: hydroxylamine hydrochloride / methanol / 16 h / 25 °C / Inert atmosphere

With diethylamino-sulfur trifluoride; hydroxylamine hydrochloride; In methanol; dichloromethane;
DOI:10.1021/ol102454e

Reference yield:

: 1192017-87-0
N-(1-(methoxy(methyl)amino)-2-methyl-1-oxopropan-2-yl)benzamide

: 1260435-58-2
5,5-dimethyl-3-phenyl-6-(phenylethynyl)-5,6-dihydro-4H-1,2,4-oxadiazin-6-ol

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / -30 - 20 °C / Inert atmosphere

2: diethylamino-sulfur trifluoride / dichloromethane / 0.5 h / -10 - 20 °C / Inert atmosphere

3: hydroxylamine hydrochloride / methanol / 16 h / 25 °C / Inert atmosphere

With diethylamino-sulfur trifluoride; hydroxylamine hydrochloride; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/ol102454e