N-{3-[(2-naphthalenyloxy)methyl]benzoyl}-β-alanine methyl ester

Base Information

• Chemical Name: N-{3-[(2-naphthalenyloxy)methyl]benzoyl}-β-alanine methyl ester
• CAS No.: 102650-14-6
• Molecular Formula: C₂₂H₂₁NO₄
• Molecular Weight: 363.413
• Mol file: 102650-14-6.mol

Synonyms:N-{3-[(2-naphthalenyloxy)methyl]benzoyl}-β-alanine methyl ester

Chemical Property of N-{3-[(2-naphthalenyloxy)methyl]benzoyl}-β-alanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-{3-[(2-naphthalenyloxy)methyl]benzoyl}-β-alanine methyl ester

There total 5 articles about N-{3-[(2-naphthalenyloxy)methyl]benzoyl}-β-alanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

methyl 3-aminopropanoate (4138-35-6) + 3-(Naphthalen-2-yloxymethyl)-benzoyl chloride → N-{3-[(2-naphthalenyloxy)methyl]benzoyl}-β-alanine methyl ester (102650-14-6)

Guidance literature:

With triethylamine; In dichloromethane; for 0.5h;

DOI:10.1021/jm00158a019

Reference yield:

3-(Naphthalen-2-yloxymethyl)-benzoic acid (438464-01-8) → N-{3-[(2-naphthalenyloxy)methyl]benzoyl}-β-alanine methyl ester (102650-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / toluene; dimethylformamide / 0.5 h / 120 °C

2: 76 percent / triethylamine / CH₂Cl₂ / 0.5 h

With oxalyl dichloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00158a019

Reference yield:

3-(Naphthalen-2-yloxymethyl)-benzoic acid methyl ester (438464-66-5) → N-{3-[(2-naphthalenyloxy)methyl]benzoyl}-β-alanine methyl ester (102650-14-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1N aq. sodium hydroxide / methanol / 2 h / 90 °C

2: oxalyl chloride / toluene; dimethylformamide / 0.5 h / 120 °C

3: 76 percent / triethylamine / CH₂Cl₂ / 0.5 h

With sodium hydroxide; oxalyl dichloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00158a019

upstream raw materials:

methyl 3-aminopropanoate

3-(Naphthalen-2-yloxymethyl)-benzoic acid

3-(Naphthalen-2-yloxymethyl)-benzoic acid methyl ester

3-methoxycarbonylbenzyl bromide

Downstream raw materials:

3-[3-(Naphthalen-2-yloxymethyl)-benzoylamino]-propionic acid