C₁₈H₁₂FN₃O₃S

Base Information

Chemical Name:C₁₈H₁₂FN₃O₃S
CAS No.:1312435-93-0
Molecular Formula:C₁₈H₁₂FN₃O₃S
Molecular Weight:369.376
Hs Code.:

C<sub>18</sub>H<sub>12</sub>FN<sub>3</sub>O<sub>3</sub>S

Synonyms:C₁₈H₁₂FN₃O₃S

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Chemical Property of C₁₈H₁₂FN₃O₃S

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Technology Process of C₁₈H₁₂FN₃O₃S

There total 8 articles about C₁₈H₁₂FN₃O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1312435-92-9
C₂₂H₂₀FN₃O₃S

: 1312435-93-0
C₁₈H₁₂FN₃O₃S

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 4519-40-8
2,3-difluoroanilline

: 1312435-93-0
C₁₈H₁₂FN₃O₃S

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / Cooling with ice

2.1: dichloromethane / 1 h / 20 °C

3.1: Lawessons reagent / toluene / 1 h / Reflux

3.2: 1 h / Reflux

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -60 °C / Inert atmosphere

4.2: 3 h / 20 °C

5.1: hydrazine hydrate / ethanol / 4 h / Reflux

6.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

7.1: Burgess Reagent / 1,4-dioxane / 2 h / 90 °C

8.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

9.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With Lawessons reagent; N-Bromosuccinimide; Burgess Reagent; sodium carbonate; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1312435-91-8
C₁₆H₁₅BrFN₃O₃S

: 1312435-93-0
C₁₈H₁₂FN₃O₃S

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With sodium carbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water;