2-(hydroxymethyl)-2-{[4-(2,2,2-trifluoroacetamido)phenyl]methyl}-1,3-di(2,2,2-trifluoroacetoxy)propane

Base Information

Chemical Name:2-(hydroxymethyl)-2-{[4-(2,2,2-trifluoroacetamido)phenyl]methyl}-1,3-di(2,2,2-trifluoroacetoxy)propane
CAS No.:419563-73-8
Molecular Formula:C₁₇H₁₄F₉NO₆
Molecular Weight:499.287
Hs Code.:

Synonyms:2-(hydroxymethyl)-2-{[4-(2,2,2-trifluoroacetamido)phenyl]methyl}-1,3-di(2,2,2-trifluoroacetoxy)propane

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Chemical Property of 2-(hydroxymethyl)-2-{[4-(2,2,2-trifluoroacetamido)phenyl]methyl}-1,3-di(2,2,2-trifluoroacetoxy)propane

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Technology Process of 2-(hydroxymethyl)-2-{[4-(2,2,2-trifluoroacetamido)phenyl]methyl}-1,3-di(2,2,2-trifluoroacetoxy)propane

There total 6 articles about 2-(hydroxymethyl)-2-{[4-(2,2,2-trifluoroacetamido)phenyl]methyl}-1,3-di(2,2,2-trifluoroacetoxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 419563-72-7
2-(benzyloxymethyl)-2-{[4-(2,2,2-trifluoroacetamido)phenyl]methyl}-1,3-di(2,2,2-trifluoroacetoxy)propane

: 419563-73-8
2-(hydroxymethyl)-2-{[4-(2,2,2-trifluoroacetamido)phenyl]methyl}-1,3-di(2,2,2-trifluoroacetoxy)propane

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 50 ℃; for 5h;
DOI:10.1055/s-2002-19291

Reference yield:

: 7598-70-1
diethyl 2-(4-nitrobenzyl)malonate

: 419563-73-8
2-(hydroxymethyl)-2-{[4-(2,2,2-trifluoroacetamido)phenyl]methyl}-1,3-di(2,2,2-trifluoroacetoxy)propane

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / tetrahydrofuran / 0.17 h

1.2: tetrahydrofuran / 5 h / Heating

2.1: NaBH₄ / ethanol / 16 h / Heating

3.1: H₂ / 10 percent Pd/C / ethyl acetate / 3 h / 2062.66 Torr

4.1: pyridine / 20 h / 20 °C

5.1: 1.39 g / H₂ / 10 percent Pd/C / ethyl acetate / 5 h / 50 °C

With pyridine; sodium tetrahydroborate; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate;
DOI:10.1055/s-2002-19291

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 419563-73-8
2-(hydroxymethyl)-2-{[4-(2,2,2-trifluoroacetamido)phenyl]methyl}-1,3-di(2,2,2-trifluoroacetoxy)propane

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

1.2: 52 percent / tetrahydrofuran / 3 h / Heating

2.1: NaH / tetrahydrofuran / 0.17 h

2.2: tetrahydrofuran / 5 h / Heating

3.1: NaBH₄ / ethanol / 16 h / Heating

4.1: H₂ / 10 percent Pd/C / ethyl acetate / 3 h / 2062.66 Torr

5.1: pyridine / 20 h / 20 °C

6.1: 1.39 g / H₂ / 10 percent Pd/C / ethyl acetate / 5 h / 50 °C

With pyridine; sodium tetrahydroborate; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; ethyl acetate;
DOI:10.1055/s-2002-19291