5-(((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-3a-((S)-2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)-5a,5b,8,8,11a-pentamethylicosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)-3,3-dimethyl-5-oxopentanoic acid

Base Information

Chemical Name:5-(((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-3a-((S)-2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)-5a,5b,8,8,11a-pentamethylicosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)-3,3-dimethyl-5-oxopentanoic acid
CAS No.:1616704-97-2
Molecular Formula:C₅₁H₇₅N₃O₆
Molecular Weight:826.173
Hs Code.:

5-(((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-3a-((S)-2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)-5a,5b,8,8,11a-pentamethylicosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)-3,3-dimethyl-5-oxopentanoic acid

Synonyms:5-(((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-3a-((S)-2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)-5a,5b,8,8,11a-pentamethylicosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)-3,3-dimethyl-5-oxopentanoic acid

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Chemical Property of 5-(((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-3a-((S)-2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)-5a,5b,8,8,11a-pentamethylicosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)-3,3-dimethyl-5-oxopentanoic acid

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Technology Process of 5-(((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-3a-((S)-2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)-5a,5b,8,8,11a-pentamethylicosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)-3,3-dimethyl-5-oxopentanoic acid

There total 10 articles about 5-(((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-3a-((S)-2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)-5a,5b,8,8,11a-pentamethylicosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)-3,3-dimethyl-5-oxopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.3%

: 4160-82-1
3,3-dimethylglutaric anhydride

: 1616705-57-7
((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-1-isopropyl-5a,5b,8,8,11a-pentamethylicosahydro-3aH-cyclopenta[a]chrysen-3a-yl)((S)-2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)pyrrolidin-1-yl)methanone

: 1616704-97-2
5-(((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-3a-((S)-2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)-5a,5b,8,8,11a-pentamethylicosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)-3,3-dimethyl-5-oxopentanoic acid

Guidance literature:: With dmap; In toluene; at 90 ℃; for 12h;

Reference yield:

: 25488-54-4
(1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-acetoxy-1-isopropyl-5a,5b,8,8,11a-pentamethylicosahydro-3aH-cyclopenta[a]chrysene-3a-carboxylic acid

: 1616704-97-2
5-(((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-3a-((S)-2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)-5a,5b,8,8,11a-pentamethylicosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)-3,3-dimethyl-5-oxopentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C

2: triethylamine / dichloromethane / 14 h / 0 - 20 °C

3: sodium hydroxide; water / methanol; tetrahydrofuran / 12 h / 0 - 20 °C

4: dmap / toluene / 12 h / 90 °C

With dmap; oxalyl dichloride; water; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;

Reference yield:

: 59837-68-2
Acetyl-dihydrobetulinsaeurechlorid

: 1616704-97-2
5-(((1S,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-1-isopropyl-3a-((S)-2-(5-(4-methoxyphenyl)-1H-imidazol-2-yl)pyrrolidine-1-carbonyl)-5a,5b,8,8,11a-pentamethylicosahydro-1H-cyclopenta[a]chrysen-9-yl)oxy)-3,3-dimethyl-5-oxopentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 14 h / 0 - 20 °C

2: sodium hydroxide; water / methanol; tetrahydrofuran / 12 h / 0 - 20 °C

3: dmap / toluene / 12 h / 90 °C

With dmap; water; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; toluene;