[5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl sulfamate

Base Information

Chemical Name:[5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl sulfamate
CAS No.:25030-31-3
Molecular Formula:C₁₀H₁₄N₆O₆S
Molecular Weight:346.324
Hs Code.:29339900
NSC Number:133114
DSSTox Substance ID:DTXSID30947893
ChEMBL ID:CHEMBL18001
Mol file:25030-31-3.mol

Synonyms:5'-sulfamoyladenosine

Suppliers and Price of [5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl sulfamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5’-Sulfamoyladenosine
10mg
$ 185.00

Total 9 raw suppliers

Chemical Property of [5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl sulfamate

Chemical Property:

Melting Point:170 °C
Boiling Point:762.4±70.0 °C(Predicted)
PKA:9.15±0.70(Predicted)
Flash Point:414.9oC
PSA：197.08000
Density:2.24±0.1 g/cm3(Predicted)
LogP:-0.38990
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)
XLogP3:-3
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:4
Exact Mass:346.06955336
Heavy Atom Count:23
Complexity:530

Purity/Quality:

99% ^*data from raw suppliers

5’-Sulfamoyladenosine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COS(=O)(=O)N)O)O)N
Uses 5’Sulfamoyladenosine is used in studies relating to novel parasite inhibitors. In addition, it is used in the design and synthesis of β-ketosulfonamide adenylation inhibitors, as antitubercular antib iotics. 5’-Sulfamoyladenosine is used in studies relating to novel parasite inhibitors. In addition, it is used in the design and synthesis of β-ketosulfonamide adenylation inhibitors, as antitubercular antibiotics.

Technology Process of [5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl sulfamate

There total 12 articles about [5-(6-Aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl sulfamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 863238-53-3
2',3'-O-bis(tert-butyldimethylsilyl)-5'-O-(sulfamoyl)adenosine

: 25030-31-3
5'-Sulfamoyladenosine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield: 50.0%

: 112921-00-3
((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate

: 25030-31-3
5'-Sulfamoyladenosine

Guidance literature:: ((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl sulfamate; With water; trifluoroacetic acid; at 20 ℃; for 1h;

With ammonium hydroxide; In methanol; dichloromethane;
DOI:10.1021/ml2000615

Reference yield: 39.0%

: 1356085-30-7
6-N-benzyloxycarbonyl-2',3'-O-benzylidene-5'-O-[N-(N-Cbz)-L-homoserinyl(OBn)sulfamoyl]adenosine

: 25030-31-3
5'-Sulfamoyladenosine

: 5'-O-(N-homoserinylsulfamoyl)adenosine

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In water; isopropyl alcohol; at 70 ℃; for 2h; under 37503.8 Torr; Continuous-flow hydrogenation reactor;
DOI:10.1016/j.tet.2011.12.011