(2S,2'S)-tert-butyl 2,2'-(5,5'-(biphenyl-4,4'-diyl)bis(1H-pyrazole-5,3-diyl))dipyrrolidine-1-carboxylate

Base Information

Chemical Name:(2S,2'S)-tert-butyl 2,2'-(5,5'-(biphenyl-4,4'-diyl)bis(1H-pyrazole-5,3-diyl))dipyrrolidine-1-carboxylate
CAS No.:1085706-41-7
Molecular Formula:C₃₆H₄₄N₆O₄
Molecular Weight:624.783
Hs Code.:

Synonyms:(2S,2'S)-tert-butyl 2,2'-(5,5'-(biphenyl-4,4'-diyl)bis(1H-pyrazole-5,3-diyl))dipyrrolidine-1-carboxylate

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Chemical Property of (2S,2'S)-tert-butyl 2,2'-(5,5'-(biphenyl-4,4'-diyl)bis(1H-pyrazole-5,3-diyl))dipyrrolidine-1-carboxylate

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Technology Process of (2S,2'S)-tert-butyl 2,2'-(5,5'-(biphenyl-4,4'-diyl)bis(1H-pyrazole-5,3-diyl))dipyrrolidine-1-carboxylate

There total 6 articles about (2S,2'S)-tert-butyl 2,2'-(5,5'-(biphenyl-4,4'-diyl)bis(1H-pyrazole-5,3-diyl))dipyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1085706-40-6
(S)-tert-butyl 2-(5-(4-iodophenyl)-1H-pyrazol-3-yl)pyrrolidine-1-carboxylate

: 1085706-38-2
(S)-tert-butyl 2-(5-(4-bromophenyl)-1H-pyrazol-3-yl)pyrrolidine-1-carboxylate

: 1085706-41-7
(2S,2'S)-tert-butyl 2,2'-(5,5'-(biphenyl-4,4'-diyl)bis(1H-pyrazole-5,3-diyl))dipyrrolidine-1-carboxylate

Guidance literature:: (S)-tert-butyl 2-(5-(4-bromophenyl)-1H-pyrazol-3-yl)pyrrolidine-1-carboxylate; With methyllithium; tert.-butyl lithium; In tetrahydrofuran; diethyl ether; pentane; at -78 ℃; for 0.166667h;

With zinc(II) chloride; In tetrahydrofuran; diethyl ether; pentane; for 0.5h;

(S)-tert-butyl 2-(5-(4-iodophenyl)-1H-pyrazol-3-yl)pyrrolidine-1-carboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; pentane; at 70 ℃; for 12h;

Reference yield:

: 766-96-1
4-bromo-1-ethynylbenzene

: 1085706-41-7
(2S,2'S)-tert-butyl 2,2'-(5,5'-(biphenyl-4,4'-diyl)bis(1H-pyrazole-5,3-diyl))dipyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 1.17 h / -78 - 20 °C

1.2: 2 h / 0 - 20 °C

2.1: hydrazine / ethanol; water / 16 h / 80 °C

3.1: methyllithium; tert.-butyl lithium / tetrahydrofuran; diethyl ether; pentane / 0.17 h / -78 °C

3.2: 0.5 h

3.3: 12 h / 70 °C

With ethylmagnesium bromide; methyllithium; tert.-butyl lithium; hydrazine; In tetrahydrofuran; diethyl ether; ethanol; water; pentane;

Reference yield:

: 1085706-39-3
(S)-tert-butyl 2-(3-(4-iodophenyl)propioloyl)pyrrolidine-1-carboxylate

: 1085706-41-7
(2S,2'S)-tert-butyl 2,2'-(5,5'-(biphenyl-4,4'-diyl)bis(1H-pyrazole-5,3-diyl))dipyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrazine / ethanol; water / 3 h / 85 °C

2.1: methyllithium; tert.-butyl lithium / tetrahydrofuran; diethyl ether; pentane / 0.17 h / -78 °C

2.2: 0.5 h

2.3: 12 h / 70 °C

With methyllithium; tert.-butyl lithium; hydrazine; In tetrahydrofuran; diethyl ether; ethanol; water; pentane;