(R)-benzyl 2-(2-methoxy-2-oxoethyl)-5,5-dimethyltetrahydrofuran-2-carboxylate

Base Information

Chemical Name:(R)-benzyl 2-(2-methoxy-2-oxoethyl)-5,5-dimethyltetrahydrofuran-2-carboxylate
CAS No.:1040272-35-2
Molecular Formula:C₁₇H₂₂O₅
Molecular Weight:306.359
Hs Code.:

Synonyms:(R)-benzyl 2-(2-methoxy-2-oxoethyl)-5,5-dimethyltetrahydrofuran-2-carboxylate

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Chemical Property of (R)-benzyl 2-(2-methoxy-2-oxoethyl)-5,5-dimethyltetrahydrofuran-2-carboxylate

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Technology Process of (R)-benzyl 2-(2-methoxy-2-oxoethyl)-5,5-dimethyltetrahydrofuran-2-carboxylate

There total 4 articles about (R)-benzyl 2-(2-methoxy-2-oxoethyl)-5,5-dimethyltetrahydrofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1040271-95-1
(R)-1-benzyl 4-methyl 2-hydroxy-2-(3-methylbut-2-enyl)succinate

: 1040272-35-2
(R)-benzyl 2-(2-methoxy-2-oxoethyl)-5,5-dimethyltetrahydrofuran-2-carboxylate

Guidance literature:: (R)-1-benzyl 4-methyl 2-hydroxy-2-(3-methylbut-2-enyl)succinate; With mercury(II) diacetate; In tetrahydrofuran; water; at 23 ℃; for 0.75h; Inert atmosphere;

With sodium hydroxide; sodium tetrahydroborate; In tetrahydrofuran; water; at 23 ℃; Inert atmosphere;
DOI:10.1002/chem.200701998

Reference yield:

: 864081-87-8
(2R,4R)-[2-tert-butyl-4-(3-methylbut-2-enyl)-5-oxo-1,3-dioxolan-4-yl]acetic acid

: 1040272-35-2
(R)-benzyl 2-(2-methoxy-2-oxoethyl)-5,5-dimethyltetrahydrofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C

2.1: methanol; benzene / 23 °C / Inert atmosphere

3.1: mercury(II) diacetate / tetrahydrofuran; water / 0.75 h / 23 °C / Inert atmosphere

3.2: 0.08 h / 23 °C / Inert atmosphere

With mercury(II) diacetate; sodium hydride; In tetrahydrofuran; methanol; water; benzene;

Reference yield:

: 910138-91-9
(-)-2-hydroxy-2-(3-methylbut-2-enyl)succinic acid 1-benzyl ester

: 1040272-35-2
(R)-benzyl 2-(2-methoxy-2-oxoethyl)-5,5-dimethyltetrahydrofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; benzene / 23 °C / Inert atmosphere

2.1: mercury(II) diacetate / tetrahydrofuran; water / 0.75 h / 23 °C / Inert atmosphere

2.2: 0.08 h / 23 °C / Inert atmosphere

With mercury(II) diacetate; In tetrahydrofuran; methanol; water; benzene;