(2S,3S)-(+)-ethyl-2-methyl-3-hydroxybutanoate t-butyldiphenylsilylether

Base Information

Chemical Name:(2S,3S)-(+)-ethyl-2-methyl-3-hydroxybutanoate t-butyldiphenylsilylether
CAS No.:121404-76-0
Molecular Formula:C₂₃H₃₂O₃Si
Molecular Weight:384.591
Hs Code.:

Synonyms:(2S,3S)-(+)-ethyl-2-methyl-3-hydroxybutanoate t-butyldiphenylsilylether

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-(+)-ethyl-2-methyl-3-hydroxybutanoate t-butyldiphenylsilylether

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Technology Process of (2S,3S)-(+)-ethyl-2-methyl-3-hydroxybutanoate t-butyldiphenylsilylether

There total 1 articles about (2S,3S)-(+)-ethyl-2-methyl-3-hydroxybutanoate t-butyldiphenylsilylether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 78088-28-5
ethyl (2S,3S)-3-hydroxy-2-methylbutanoate

: 58479-61-1
tert-butylchlorodiphenylsilane

: 121404-76-0
(2S,3S)-(+)-ethyl-2-methyl-3-hydroxybutanoate t-butyldiphenylsilylether

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 72h; Ambient temperature;
DOI:10.1016/S0040-4020(01)89828-8

Reference yield: 75.0%

: 121404-76-0
(2S,3S)-(+)-ethyl-2-methyl-3-hydroxybutanoate t-butyldiphenylsilylether

: 121429-51-4
(2R,3S)-(+)-2-methyl-1,3-butanediol-3 t-butyldiphenylsilylether

Guidance literature:: With diisobutylaluminium hydride; In diethyl ether; 1.) -78 deg C, 1 h 2.) -55 deg C, 3 h;
DOI:10.1016/S0040-4020(01)89828-8

Reference yield:

: 121404-76-0
(2S,3S)-(+)-ethyl-2-methyl-3-hydroxybutanoate t-butyldiphenylsilylether

: 121404-81-7
tert-Butyl-diphenyl-((2R,6R)-1,2,6-trimethyl-tetradecyloxy)-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / DIBAH / diethyl ether / 1.) -78 deg C, 1 h 2.) -55 deg C, 3 h

2: 85 percent / pyridine / CH₂Cl₂ / 12 h / 0 °C

3: 100 percent / LiBr / tetrahydrofuran / 12 h / Ambient temperature

4: 74 percent / LDA, HMPT / tetrahydrofuran / 4 h / -52 °C

5: 63 percent / Na(Hg), Na₂HPO₄ / methanol; tetrahydrofuran / Ambient temperature

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; disodium hydrogenphosphate; sodium amalgam; diisobutylaluminium hydride; lithium bromide; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4020(01)89828-8