(R)-2-(4-(1H-indol-5-yl)phenyl)-8-benzyl-3-((1-(cyclopropanecarbonyl) pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

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Chemical Name:(R)-2-(4-(1H-indol-5-yl)phenyl)-8-benzyl-3-((1-(cyclopropanecarbonyl) pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one
CAS No.:1579514-59-2
Molecular Formula:C₃₇H₃₉N₅O₂
Molecular Weight:585.749
Hs Code.:

Synonyms:(R)-2-(4-(1H-indol-5-yl)phenyl)-8-benzyl-3-((1-(cyclopropanecarbonyl) pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

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Chemical Property of (R)-2-(4-(1H-indol-5-yl)phenyl)-8-benzyl-3-((1-(cyclopropanecarbonyl) pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

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Technology Process of (R)-2-(4-(1H-indol-5-yl)phenyl)-8-benzyl-3-((1-(cyclopropanecarbonyl) pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

There total 9 articles about (R)-2-(4-(1H-indol-5-yl)phenyl)-8-benzyl-3-((1-(cyclopropanecarbonyl) pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1579514-72-9
(R)-8-benzyl-2-(4-bromophenyl)-3-((1-(cyclopropanecarbonyl)pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

: 144104-59-6
1H-indole-5-boronic acid

: 1579514-59-2
(R)-2-(4-(1H-indol-5-yl)phenyl)-8-benzyl-3-((1-(cyclopropanecarbonyl) pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; for 16h; Reflux;

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1579514-59-2
(R)-2-(4-(1H-indol-5-yl)phenyl)-8-benzyl-3-((1-(cyclopropanecarbonyl) pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium chloride; ammonia / water / 0.33 h / 20 °C

1.2: 24 h

2.1: sulfuric acid / dichloromethane / 0 - 5 °C

2.2: 10 °C / pH 9

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

4.1: sodium hydroxide / water; methanol / 24 h / 65 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 65 °C

6.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

7.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

8.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 16 h / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; ammonia; potassium carbonate; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 136624-42-5
4-amino-1-benzylpiperidine-4-carbonitrile

: 1579514-59-2
(R)-2-(4-(1H-indol-5-yl)phenyl)-8-benzyl-3-((1-(cyclopropanecarbonyl) pyrrolidin-3-yl)methyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / dichloromethane / 0 - 5 °C

1.2: 10 °C / pH 9

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: sodium hydroxide / water; methanol / 24 h / 65 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 65 °C

5.1: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C

7.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,4-dioxane / 16 h / Reflux

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;