Technology Process of 1-[2-hydroxy-4,6-dimethoxy-3-(2-methyl-2H-tetrazole-5-yl)-phenyl]ethanone
There total 4 articles about 1-[2-hydroxy-4,6-dimethoxy-3-(2-methyl-2H-tetrazole-5-yl)-phenyl]ethanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-methyl-5-(2,4,6-trimethoxy-phenyl)-2H-tetrazole; acetic anhydride;
With
boron trifluoride diethyl etherate;
at 0 - 20 ℃;
for 4h;
Inert atmosphere;
With
water; sodium carbonate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: trichlorophosphate / -5 - 0 °C / Inert atmosphere
2.1: iodine; ammonia / water; tetrahydrofuran / 1 h / 20 °C
3.1: sodium azide; zinc dibromide / water / 24 h / Reflux
3.2: pH 1
4.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C / 2068.65 Torr / Inert atmosphere
5.1: boron trifluoride diethyl etherate / 4 h / 0 - 20 °C / Inert atmosphere
With
sodium azide; boron trifluoride diethyl etherate; ammonia; hydrogen; iodine; zinc dibromide; trichlorophosphate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; water;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium azide; zinc dibromide / water / 24 h / Reflux
1.2: pH 1
2.1: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 20 °C / 2068.65 Torr / Inert atmosphere
3.1: boron trifluoride diethyl etherate / 4 h / 0 - 20 °C / Inert atmosphere
With
sodium azide; boron trifluoride diethyl etherate; hydrogen; zinc dibromide;
palladium 10% on activated carbon;
In
methanol; water;
