5-methoxy-4'-methyl-1'-tosyl-1',5'-dihydrospiro[isochroman-4,2'-pyrrole]

Base Information

Chemical Name:5-methoxy-4'-methyl-1'-tosyl-1',5'-dihydrospiro[isochroman-4,2'-pyrrole]
CAS No.:1393135-45-9
Molecular Formula:C₂₁H₂₃NO₄S
Molecular Weight:385.484
Hs Code.:

Synonyms:5-methoxy-4'-methyl-1'-tosyl-1',5'-dihydrospiro[isochroman-4,2'-pyrrole]

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Chemical Property of 5-methoxy-4'-methyl-1'-tosyl-1',5'-dihydrospiro[isochroman-4,2'-pyrrole]

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Technology Process of 5-methoxy-4'-methyl-1'-tosyl-1',5'-dihydrospiro[isochroman-4,2'-pyrrole]

There total 4 articles about 5-methoxy-4'-methyl-1'-tosyl-1',5'-dihydrospiro[isochroman-4,2'-pyrrole] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1373263-79-6
2-(3-((3-methoxybenzyl)oxy)prop-1-yn-1-yl)-2-methyl-1-tosylaziridine

: 1373263-89-8
7-methoxy-4'-methyl-1'-tosyl-1',5'-dihydrospiro[isochroman-4,2'-pyrrole]

: 1393135-45-9
5-methoxy-4'-methyl-1'-tosyl-1',5'-dihydrospiro[isochroman-4,2'-pyrrole]

Guidance literature:: With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold (I); In dichloromethane; at 0 - 20 ℃; for 0.5h;
DOI:10.1021/jo300294r

Reference yield:

: 10605-68-2
4-methyl-4-penten-2-yn-1-ol

: 1373263-89-8
7-methoxy-4'-methyl-1'-tosyl-1',5'-dihydrospiro[isochroman-4,2'-pyrrole]

: 1393135-45-9
5-methoxy-4'-methyl-1'-tosyl-1',5'-dihydrospiro[isochroman-4,2'-pyrrole]

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra-(n-butyl)ammonium iodide; sodium hydride / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: tetrakis(acetonitrile)copper(I) perchlorate / acetonitrile / 20 °C / Molecular sieve; Inert atmosphere

3.1: [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold (I) / dichloromethane / 0.5 h / 0 - 20 °C

With tetrakis(acetonitrile)copper(I) perchlorate; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold (I); tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jo300294r

Reference yield:

: 1373264-11-9
1-methoxy-3-(((4-methylpent-4-en-2-yn-1-yl)oxy)methyl)-benzene

: 1373263-89-8
7-methoxy-4'-methyl-1'-tosyl-1',5'-dihydrospiro[isochroman-4,2'-pyrrole]

: 1393135-45-9
5-methoxy-4'-methyl-1'-tosyl-1',5'-dihydrospiro[isochroman-4,2'-pyrrole]

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(acetonitrile)copper(I) perchlorate / acetonitrile / 20 °C / Molecular sieve; Inert atmosphere

2: [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold (I) / dichloromethane / 0.5 h / 0 - 20 °C

With tetrakis(acetonitrile)copper(I) perchlorate; [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold (I); In dichloromethane; acetonitrile;
DOI:10.1021/jo300294r