[1-(3,4-DICHLOROBENZOYL)-4-FLUORO-4-PIPERIDINYL]METHYL 4-METHYLBENZENESULFONATE

Base Information

Chemical Name:[1-(3,4-DICHLOROBENZOYL)-4-FLUORO-4-PIPERIDINYL]METHYL 4-METHYLBENZENESULFONATE
CAS No.:208111-55-1
Molecular Formula:C₂₀H₂₀Cl₂FNO₄S
Molecular Weight:460.354
Hs Code.:
Mol file:208111-55-1.mol

Synonyms:N-(3,4-dichlorobenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine

Suppliers and Price of [1-(3,4-DICHLOROBENZOYL)-4-FLUORO-4-PIPERIDINYL]METHYL 4-METHYLBENZENESULFONATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

American Custom Chemicals Corporation
[1-(3,4-DICHLOROBENZOYL)-4-FLUORO-4-PIPERIDINYL]METHYL 4-METHYLBENZENESULFONATE 95.00%
5MG
$ 687.35

American Custom Chemicals Corporation
[1-(3,4-DICHLOROBENZOYL)-4-FLUORO-4-PIPERIDINYL]METHYL 4-METHYLBENZENESULFONATE 95.00%
10MG
$ 679.14

American Custom Chemicals Corporation
[1-(3,4-DICHLOROBENZOYL)-4-FLUORO-4-PIPERIDINYL]METHYL 4-METHYLBENZENESULFONATE 95.00%
1MG
$ 647.61

Total 0 raw suppliers

Chemical Property of [1-(3,4-DICHLOROBENZOYL)-4-FLUORO-4-PIPERIDINYL]METHYL 4-METHYLBENZENESULFONATE

Chemical Property:

Purity/Quality:: [1-(3,4-DICHLOROBENZOYL)-4-FLUORO-4-PIPERIDINYL]METHYL 4-METHYLBENZENESULFONATE 95.00% ^*data from reagent suppliers

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Technology Process of [1-(3,4-DICHLOROBENZOYL)-4-FLUORO-4-PIPERIDINYL]METHYL 4-METHYLBENZENESULFONATE

There total 6 articles about [1-(3,4-DICHLOROBENZOYL)-4-FLUORO-4-PIPERIDINYL]METHYL 4-METHYLBENZENESULFONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 98-59-9
p-toluenesulfonyl chloride

: 223632-79-9
N-(3,4-dichlorobenzoyl)-4-fluoro-4-hydroxymethylpiperidine

: 208111-55-1
N-(3,4-dichlorobenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine

Guidance literature:: With pyridine; Ambient temperature;
DOI:10.1021/jm9806906

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 208111-55-1
N-(3,4-dichlorobenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: TEA / CHCl₃ / 17 h / Ambient temperature

2: 80 percent aq. formic acid, CuSO₄ / 16 h / 80 °C

3: dimethylsulfoxide / 3.5 h / 60 °C

4: 46 percent / HF*pyridine / CH₂Cl₂ / a) -10 deg C, 15 min, b) RT, 16 h

5: 81 percent / pyridine / Ambient temperature

With pyridine; formic acid; TEA; pyridine hydrogenfluoride; copper(II) sulfate; In dichloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm9806906

Reference yield:

: 3024-72-4
3,4-dichlorobenzoyl chloride

: 208111-55-1
N-(3,4-dichlorobenzoyl)-4-fluoro-4-(4-methylphenylsulonuloxymethyl)-piperidine

Guidance literature:: Multi-step reaction with 5 steps

1: TEA / CHCl₃ / 17 h / Ambient temperature

2: 80 percent aq. formic acid, CuSO₄ / 16 h / 80 °C

3: dimethylsulfoxide / 3.5 h / 60 °C

4: 46 percent / HF*pyridine / CH₂Cl₂ / a) -10 deg C, 15 min, b) RT, 16 h

5: 81 percent / pyridine / Ambient temperature

With pyridine; formic acid; TEA; pyridine hydrogenfluoride; copper(II) sulfate; In dichloromethane; chloroform; dimethyl sulfoxide;
DOI:10.1021/jm9806906