Technology Process of (4R,6R)-6-Allyl-4-methoxy-6-((S)-1-methyl-2,2-bis-methylsulfanyl-ethyl)-cyclohex-2-enone
There total 11 articles about (4R,6R)-6-Allyl-4-methoxy-6-((S)-1-methyl-2,2-bis-methylsulfanyl-ethyl)-cyclohex-2-enone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
3: 33 percent / NaHCO3 / methanol / 50 °C
4: 1.) THF, - 78 deg C 2.) HMPA, -78 deg C
5: (n-Bu)4N(1+)*F(1-) / tetrahydrofuran
6: 1.) KOH, KH / 1.) THF, reflux 2.) -78 to room temp.
7: 82 percent / tetrahydrofuran / -20 °C
8: 87 percent / c.HCl / methanol
9: 67 percent / pyridine*SO3, Et3N / dimethylsulfoxide
10: NaHCO3 / methanol / Heating; Var. solv.
With
hydrogenchloride; potassium hydroxide; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; potassium hydride; sodium hydrogencarbonate; triethylamine;
In
tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)61960-3
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 33 percent / NaHCO3 / methanol / 50 °C
2: 1.) THF, - 78 deg C 2.) HMPA, -78 deg C
3: (n-Bu)4N(1+)*F(1-) / tetrahydrofuran
4: 1.) KOH, KH / 1.) THF, reflux 2.) -78 to room temp.
5: 82 percent / tetrahydrofuran / -20 °C
6: 87 percent / c.HCl / methanol
7: 67 percent / pyridine*SO3, Et3N / dimethylsulfoxide
8: NaHCO3 / methanol / Heating; Var. solv.
With
hydrogenchloride; potassium hydroxide; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; potassium hydride; sodium hydrogencarbonate; triethylamine;
In
tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)61960-3
- Guidance literature:
-
Multi-step reaction with 9 steps
2: 33 percent / NaHCO3 / methanol / 50 °C
3: 1.) THF, - 78 deg C 2.) HMPA, -78 deg C
4: (n-Bu)4N(1+)*F(1-) / tetrahydrofuran
5: 1.) KOH, KH / 1.) THF, reflux 2.) -78 to room temp.
6: 82 percent / tetrahydrofuran / -20 °C
7: 87 percent / c.HCl / methanol
8: 67 percent / pyridine*SO3, Et3N / dimethylsulfoxide
9: NaHCO3 / methanol / Heating; Var. solv.
With
hydrogenchloride; potassium hydroxide; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; potassium hydride; sodium hydrogencarbonate; triethylamine;
In
tetrahydrofuran; methanol; dimethyl sulfoxide;
DOI:10.1016/S0040-4039(00)61960-3
