(4aR,5S)-5-(tert-butoxycarbonyl)amino-2-[(1S)-1-(ethoxycarbonyl)-2-phenylethyl]-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

Base Information

Chemical Name:(4aR,5S)-5-(tert-butoxycarbonyl)amino-2-[(1S)-1-(ethoxycarbonyl)-2-phenylethyl]-1,3-dioxoperhydropyrido[1,2-c]pyrimidine
CAS No.:352274-78-3
Molecular Formula:C₂₄H₃₃N₃O₆
Molecular Weight:459.543
Hs Code.:

Synonyms:(4aR,5S)-5-(tert-butoxycarbonyl)amino-2-[(1S)-1-(ethoxycarbonyl)-2-phenylethyl]-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

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Chemical Property of (4aR,5S)-5-(tert-butoxycarbonyl)amino-2-[(1S)-1-(ethoxycarbonyl)-2-phenylethyl]-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

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Technology Process of (4aR,5S)-5-(tert-butoxycarbonyl)amino-2-[(1S)-1-(ethoxycarbonyl)-2-phenylethyl]-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

There total 1 articles about (4aR,5S)-5-(tert-butoxycarbonyl)amino-2-[(1S)-1-(ethoxycarbonyl)-2-phenylethyl]-1,3-dioxoperhydropyrido[1,2-c]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 352274-76-1
2-[(3-tert-butoxycarbonylamino-2-ethoxycarbonylmethyl-piperidine-1-carbonyl)-amino]-3-phenyl-propionic acid methyl ester

: (4aS,5R)-5-(tert-butoxycarbonyl)amino-2-[(1S)-1-(methoxycarbonyl)-2-phenylethyl]-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

: (4aS,5R)-5-(tert-butoxycarbonyl)amino-2-[(1S)-1-(ethoxycarbonyl)-2-phenylethyl]-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

: 352274-78-3
(4aR,5S)-5-(tert-butoxycarbonyl)amino-2-[(1S)-1-(ethoxycarbonyl)-2-phenylethyl]-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/jm010813d

Reference yield:

: 352274-78-3
(4aR,5S)-5-(tert-butoxycarbonyl)amino-2-[(1S)-1-(ethoxycarbonyl)-2-phenylethyl]-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

: (S)-2-((4aR,5S)-5-Amino-1,3-dioxo-hexahydro-pyrido[1,2-c]pyrimidin-2-yl)-3-phenyl-propionic acid ethyl ester

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jm010813d

Reference yield:

: 352274-78-3
(4aR,5S)-5-(tert-butoxycarbonyl)amino-2-[(1S)-1-(ethoxycarbonyl)-2-phenylethyl]-1,3-dioxoperhydropyrido[1,2-c]pyrimidine

: 2-{5-[2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-propionylamino]-1,3-dioxo-hexahydro-pyrido[1,2-c]pyrimidin-2-yl}-3-phenyl-propionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂ / 0.5 h / 20 °C

2: BOP; TEA / CH₂Cl₂ / 24 h / 20 °C

With TEA; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; trifluoroacetic acid; In dichloromethane;
DOI:10.1021/jm010813d