4-[5-(chloromethyl)-1H-tetrazol-1-yl]-2-[(trifluoromethyl)oxy]benzonitrile

Base Information

Chemical Name:4-[5-(chloromethyl)-1H-tetrazol-1-yl]-2-[(trifluoromethyl)oxy]benzonitrile
CAS No.:1354948-05-2
Molecular Formula:C₁₀H₅ClF₃N₅O
Molecular Weight:303.631
Hs Code.:

Synonyms:4-[5-(chloromethyl)-1H-tetrazol-1-yl]-2-[(trifluoromethyl)oxy]benzonitrile

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Chemical Property of 4-[5-(chloromethyl)-1H-tetrazol-1-yl]-2-[(trifluoromethyl)oxy]benzonitrile

Chemical Property:

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Technology Process of 4-[5-(chloromethyl)-1H-tetrazol-1-yl]-2-[(trifluoromethyl)oxy]benzonitrile

There total 6 articles about 4-[5-(chloromethyl)-1H-tetrazol-1-yl]-2-[(trifluoromethyl)oxy]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354948-04-1
4-[5-(hydroxymethyl)-1H-tetrazol-1-yl]-2-[(trifluoromethyl)oxy]benzonitrile

: 1354948-05-2
4-[5-(chloromethyl)-1H-tetrazol-1-yl]-2-[(trifluoromethyl)oxy]benzonitrile

Guidance literature:: 4-[5-(hydroxymethyl)-1H-tetrazol-1-yl]-2-[(trifluoromethyl)oxy]benzonitrile; With thionyl chloride; In toluene; for 4h; Reflux;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 116369-25-6
4-bromo-3-(trifluoromethoxy)phenylamine

: 1354948-05-2
4-[5-(chloromethyl)-1H-tetrazol-1-yl]-2-[(trifluoromethyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / tert-butyl alcohol / 96 h

2.1: N,N-dimethyl-formamide / 15 h / Reflux

2.2: 2 h / 0 - 20 °C

3.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

4.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

4.2: 4 h / 20 °C / Reflux

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

6.1: thionyl chloride / toluene / 4 h / Reflux

With thionyl chloride; di-isopropyl azodicarboxylate; water; triethylamine; triphenylphosphine; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 609783-03-1
1,1-dimethylethyl {4-bromo-3-[(trifluoromethyl)oxy]phenyl}carbamate

: 1354948-05-2
4-[5-(chloromethyl)-1H-tetrazol-1-yl]-2-[(trifluoromethyl)oxy]benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N-dimethyl-formamide / 15 h / Reflux

1.2: 2 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 0.5 h / 0 °C

3.2: 4 h / 20 °C / Reflux

4.1: water; lithium hydroxide / tetrahydrofuran; methanol / 3 h / 0 - 20 °C

5.1: thionyl chloride / toluene / 4 h / Reflux

With thionyl chloride; di-isopropyl azodicarboxylate; water; triethylamine; triphenylphosphine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;