2-((2R,4R)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Base Information

Chemical Name:2-((2R,4R)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile
CAS No.:1283146-00-8
Molecular Formula:C₂₀H₂₁FN₂
Molecular Weight:308.399
Hs Code.:

Synonyms:2-((2R,4R)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

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Chemical Property of 2-((2R,4R)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

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Technology Process of 2-((2R,4R)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

There total 1 articles about 2-((2R,4R)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.3%

: 1312659-19-0
2-((2R,4R)-4-fluoropyrrolidin-2-yl)acetonitrile

: 1283147-19-2
1-(4-iodobenzyl)-2-methylbenzene

: 1283146-00-8
2-((2R,4R)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

Guidance literature:: With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tert-butyl alcohol; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; at 100 ℃; for 15h; Inert atmosphere;

Reference yield: 37.0%

: 79-20-9
acetic acid methyl ester

: 1283146-00-8
2-((2R,4R)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

: 1283146-01-9
methyl 2-((2R,4R)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetate

Guidance literature:: acetic acid methyl ester; 2-((2R,4R)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile; With hydrogenchloride; In methanol; dichloromethane; at 20 ℃; for 2h;

With sodium carbonate; In methanol; dichloromethane;

Reference yield:

: 1283146-00-8
2-((2R,4R)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetonitrile

: 1283142-51-7
2-((2R,4R)-4-fluoro-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / methanol; dichloromethane / 2 h / 20 °C

2: water; lithium hydroxide / tetrahydrofuran / 0 - 20 °C

With hydrogenchloride; water; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;