methyl 3-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorophenyl)-3-oxopropanoate

Base Information

• Chemical Name: methyl 3-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorophenyl)-3-oxopropanoate
• CAS No.: 1333140-89-8
• Molecular Formula: C₁₇H₁₂ClF₃O₃
• Molecular Weight: 356.729
• Mol file: 1333140-89-8.mol

Synonyms:methyl 3-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorophenyl)-3-oxopropanoate

Chemical Property of methyl 3-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorophenyl)-3-oxopropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorophenyl)-3-oxopropanoate

There total 6 articles about methyl 3-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorophenyl)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

3-(3-chloro-2-fluorobenzyl)-2,6-difluorobenzoic acid (1333140-88-7) + monomethyl monopotassium malonate (38330-80-2) → methyl 3-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorophenyl)-3-oxopropanoate (1333140-89-8)

Guidance literature:

3-(3-chloro-2-fluorobenzyl)-2,6-difluorobenzoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 2h;

monomethyl monopotassium malonate; With magnesium chloride; In tetrahydrofuran; at 50 ℃;

DOI:10.1016/j.bmc.2011.06.020

Reference yield:

methyl 3-(3-chloro-2-fluorobenzyl)-2,6-difluorobenzoate (1333140-87-6) → methyl 3-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorophenyl)-3-oxopropanoate (1333140-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 50 °C

1.2: pH 2

2.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C

2.2: 50 °C

With 1,1'-carbonyldiimidazole; lithium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.bmc.2011.06.020

Reference yield:

methyl 2,6-difluoro-3-iodobenzoate (501433-14-3) → methyl 3-(3-(3-chloro-2-fluorobenzyl)-2,6-difluorophenyl)-3-oxopropanoate (1333140-89-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: chloro-trimethyl-silane; ethylene dibromide; zinc / tetrahydrofuran / 1 h / 60 °C / Inert atmosphere

1.2: 60 °C / Inert atmosphere; Reflux

2.1: lithium hydroxide / tetrahydrofuran; water / 3 h / 50 °C

2.2: pH 2

3.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 2 h / 20 °C

3.2: 50 °C

With chloro-trimethyl-silane; ethylene dibromide; 1,1'-carbonyldiimidazole; lithium hydroxide; zinc; In tetrahydrofuran; water; 1.2: Negishi cross-coupling;

DOI:10.1016/j.bmc.2011.06.020

upstream raw materials:

methyl 3-(3-chloro-2-fluorobenzyl)-2,6-difluorobenzoate

3-(3-chloro-2-fluorobenzyl)-2,6-difluorobenzoic acid

monomethyl monopotassium malonate

2,6-difluoro-3-iodobenzoic acid

Downstream raw materials:

C₂₁H₁₉ClF₃NO₃

C₂₂H₂₁ClF₃NO₃

C₂₃H₂₃ClF₃NO₃

C₂₁H₁₉ClF₃NO₃