Technology Process of (4S,7S,8R,9aS)-4-benzyl-8-methyl-7-nitrooctahydropyrido[2,1-c][1,4]oxazin-8-ol
There total 10 articles about (4S,7S,8R,9aS)-4-benzyl-8-methyl-7-nitrooctahydropyrido[2,1-c][1,4]oxazin-8-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
In
tetrahydrofuran;
at 20 ℃;
for 5h;
optical yield given as %de;
diastereoselective reaction;
Inert atmosphere;
DOI:10.1021/ol202276h
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 4 h / 45 °C / Inert atmosphere
2: trifluorormethanesulfonic acid / dichloromethane / 5 h / -20 °C / Inert atmosphere
3: palladium on activated charcoal; hydrogen / methanol / 1 h / 20 °C
4: tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
With
Hoveyda-Grubbs catalyst second generation; trifluorormethanesulfonic acid; palladium on activated charcoal; hydrogen;
In
tetrahydrofuran; methanol; dichloromethane;
2: Aza-Michael reaction;
DOI:10.1021/ol202276h
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 4 h / 45 °C / Inert atmosphere
2: trifluorormethanesulfonic acid / dichloromethane / 5 h / -20 °C / Inert atmosphere
3: palladium on activated charcoal; hydrogen / methanol / 1 h / 20 °C
4: tetrahydrofuran / 5 h / 20 °C / Inert atmosphere
With
Hoveyda-Grubbs catalyst second generation; trifluorormethanesulfonic acid; palladium on activated charcoal; hydrogen;
In
tetrahydrofuran; methanol; dichloromethane;
2: Aza-Michael reaction;
DOI:10.1021/ol202276h
