5′-O-(4,4′-dimethoxytrityl)-N²-(dimethylformamidyl)-8-(2″-furyl)-2′-deoxyguanosine

Base Information

• Chemical Name: 5′-O-(4,4′-dimethoxytrityl)-N²-(dimethylformamidyl)-8-(2″-furyl)-2′-deoxyguanosine
• CAS No.: 1415304-21-0
• Molecular Formula: C₃₈H₃₈N₆O₇
• Molecular Weight: 690.756

Synonyms:5′-O-(4,4′-dimethoxytrityl)-N²-(dimethylformamidyl)-8-(2″-furyl)-2′-deoxyguanosine

Chemical Property of 5′-O-(4,4′-dimethoxytrityl)-N²-(dimethylformamidyl)-8-(2″-furyl)-2′-deoxyguanosine

Chemical Property:

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Technology Process of 5′-O-(4,4′-dimethoxytrityl)-N²-(dimethylformamidyl)-8-(2″-furyl)-2′-deoxyguanosine

There total 3 articles about 5′-O-(4,4′-dimethoxytrityl)-N²-(dimethylformamidyl)-8-(2″-furyl)-2′-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N2-(dimethylformamidyl)-8-(2″-furyl)-2′-deoxyguansine (1415304-20-9) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 5′-O-(4,4′-dimethoxytrityl)-N2-(dimethylformamidyl)-8-(2″-furyl)-2′-deoxyguanosine (1415304-21-0)

Guidance literature:

With pyridine; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo302164c

Reference yield:

(2''-furyl)-2'-deoxyguansine (1061729-78-9) → 5′-O-(4,4′-dimethoxytrityl)-N2-(dimethylformamidyl)-8-(2″-furyl)-2′-deoxyguanosine (1415304-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 5 h / Inert atmosphere

2: pyridine / 3 h / 20 °C / Inert atmosphere

With pyridine; In N,N-dimethyl-formamide;

DOI:10.1021/jo302164c

Reference yield:

8-bromo-2'-deoxyguanosine (13389-03-2) → 5′-O-(4,4′-dimethoxytrityl)-N2-(dimethylformamidyl)-8-(2″-furyl)-2′-deoxyguanosine (1415304-21-0)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium diacetate; trisodium tris(3-sulfophenyl)phosphine; sodium carbonate / water; acetonitrile / 100 °C

2: N,N-dimethyl-formamide / 8 h / 20 °C / Inert atmosphere

3: pyridine / Inert atmosphere

With trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; sodium carbonate; In pyridine; water; N,N-dimethyl-formamide; acetonitrile; 1: |Suzuki Coupling;

DOI:10.1021/jo4024842

upstream raw materials:

(2''-furyl)-2'-deoxyguansine

N²-(dimethylformamidyl)-8-(2″-furyl)-2′-deoxyguansine

4,4'-dimethoxytrityl chloride

8-bromo-2'-deoxyguanosine

Downstream raw materials:

3′-O-[(2-cyanoethoxy)(diisopropylamino)phosphino]-5′-O-(4,4′-dimethoxytrityl)-N²-(dimethylformamidyl)-8-(2″-furyl)-2′-deoxyguanosine

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