Bipenquinate

Base Information

• Chemical Name: Bipenquinate
• CAS No.: 96201-88-6
• Molecular Formula: C23H15 F2 N O2 . Na
• Molecular Weight: 0
• Mol file: 96201-88-6.mol

Synonyms:4-Quinolinecarboxylicacid, 6-fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-, sodium salt (9CI);Biphenquinate sodium; Brequinar sodium; DuP 785; NSC 368390

Chemical Property of Bipenquinate

Chemical Property:

• Melting Point: >360°
• Boiling Point: 550.9°Cat760mmHg
• Flash Point: 287°C
• PSA: 50.19000
• Density: g/cm³
• LogP: 5.85360
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 15 mg/ml with warming)

Purity/Quality:

97% ^*data from raw suppliers

BrequinarSodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Brequinar sodium (96201-88-6) is an inhibitor of dihydroorotate dehydrogenase (DHODH)1,2?with IC50’s between 0.2 and 5.8 μM in various cell lines3?and 20 nM in isolated enzyme4. It reduced leukemic cell burden, decreased levels of leukemia-initiating cells, and improved survival in human and mouse models of acute myeloid leukemia.4?Brequinar displayed broad antiviral activity against flaviviruses, positive-strand RNA alphaviruses, negative-strand RNA rhabdoviruses, Influenza A and B viruses, and HIV.5-7
• Uses: Antineoplastic.