Technology Process of benzhydrylidene aza-propargylglycinyl-proline methyl ester
There total 5 articles about benzhydrylidene aza-propargylglycinyl-proline methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
benzhydrylidene aza-glycinyl-proline methyl ester;
With
potassium tert-butylate;
In
tetrahydrofuran;
at 0 ℃;
for 0.25h;
Inert atmosphere;
propargyl bromide;
In
tetrahydrofuran;
at 0 - 20 ℃;
regioselective reaction;
Inert atmosphere;
DOI:10.1002/psc.1235
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
2.2: 0 - 20 °C / Inert atmosphere
With
potassium tert-butylate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/psc.1235
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dichloromethane / 0 - 20 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere
3.1: potassium tert-butylate / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
3.2: 0 - 20 °C / Inert atmosphere
With
potassium tert-butylate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1002/psc.1235
