2,4,6-Trimethyl-benzenesulfonic acid (1S,2R,3S)-2-hydroxy-1,3-dimethyl-4-trityloxy-butyl ester

Base Information

Chemical Name:2,4,6-Trimethyl-benzenesulfonic acid (1S,2R,3S)-2-hydroxy-1,3-dimethyl-4-trityloxy-butyl ester
CAS No.:87265-72-3
Molecular Formula:C₃₄H₃₈O₅S
Molecular Weight:558.739
Hs Code.:

Synonyms:2,4,6-Trimethyl-benzenesulfonic acid (1S,2R,3S)-2-hydroxy-1,3-dimethyl-4-trityloxy-butyl ester

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Chemical Property of 2,4,6-Trimethyl-benzenesulfonic acid (1S,2R,3S)-2-hydroxy-1,3-dimethyl-4-trityloxy-butyl ester

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Technology Process of 2,4,6-Trimethyl-benzenesulfonic acid (1S,2R,3S)-2-hydroxy-1,3-dimethyl-4-trityloxy-butyl ester

There total 11 articles about 2,4,6-Trimethyl-benzenesulfonic acid (1S,2R,3S)-2-hydroxy-1,3-dimethyl-4-trityloxy-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 773-64-8
2-mesitylenesulphonyl chloride

: 87265-67-6,87265-68-7
2,3-anti-3,4-syn-4-methyl-5-trityloxypentan-2,3-diol

: 87265-72-3
2,4,6-Trimethyl-benzenesulfonic acid (1S,2R,3S)-2-hydroxy-1,3-dimethyl-4-trityloxy-butyl ester

Guidance literature:: With pyridine; dmap; In benzene; Ambient temperature;
DOI:10.1016/S0040-4039(00)87971-X

Reference yield:

: 84784-84-9
(S)-5-Hydroxy-2,4-dimethyl-pent-1-en-3-one

: 87265-72-3
2,4,6-Trimethyl-benzenesulfonic acid (1S,2R,3S)-2-hydroxy-1,3-dimethyl-4-trityloxy-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: Zn(BH₄)2 / diethyl ether / 0 °C

2: pyridine / 24 h / Ambient temperature

3: O₃ / methanol / 0.05 h / -78 °C

4: Zn(BH₄)2 / diethyl ether / 0.5 h / 0 °C

5: 86 percent / 4-dimethylaminopyridine, pyridine / benzene / 120 h / Ambient temperature

With pyridine; dmap; zinc(II) tetrahydroborate; ozone; In methanol; diethyl ether; benzene;
DOI:10.1016/0040-4020(84)80005-8

Reference yield:

: 87265-64-3
t-butyl 2,4-dimethyl-3-oxo-4-pentanoate

: 87265-72-3
2,4,6-Trimethyl-benzenesulfonic acid (1S,2R,3S)-2-hydroxy-1,3-dimethyl-4-trityloxy-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: Zn(BH₄)2 / diethyl ether / 0.5 h / 0 °C

2: 100 percent / LiAlH₄ / diethyl ether / 1 h / 0 °C

3: pyridine / 24 h / Ambient temperature

4: O₃ / methanol / 0.05 h / -78 °C

5: Zn(BH₄)2 / diethyl ether / 0.5 h / 0 °C

6: 86 percent / 4-dimethylaminopyridine, pyridine / benzene / 120 h / Ambient temperature

With pyridine; dmap; lithium aluminium tetrahydride; zinc(II) tetrahydroborate; ozone; In methanol; diethyl ether; benzene;
DOI:10.1016/0040-4020(84)80005-8