ethyl (1Z)-3-phenyl-N-(1H-1,2,4-triazol-1-ylcarbonyl)propanimidoate

Base Information

• Chemical Name: ethyl (1Z)-3-phenyl-N-(1H-1,2,4-triazol-1-ylcarbonyl)propanimidoate
• CAS No.: 1233379-32-2
• Molecular Formula: C₁₄H₁₆N₄O₂
• Molecular Weight: 272.307
• Mol file: 1233379-32-2.mol

Synonyms:ethyl (1Z)-3-phenyl-N-(1H-1,2,4-triazol-1-ylcarbonyl)propanimidoate

Chemical Property of ethyl (1Z)-3-phenyl-N-(1H-1,2,4-triazol-1-ylcarbonyl)propanimidoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of ethyl (1Z)-3-phenyl-N-(1H-1,2,4-triazol-1-ylcarbonyl)propanimidoate

There total 2 articles about ethyl (1Z)-3-phenyl-N-(1H-1,2,4-triazol-1-ylcarbonyl)propanimidoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,1'-Carbonyl-di-(1,2,4-triazole) (41864-22-6) + ethyl 3-phenylpropanimidate (13226-93-2) → ethyl (1Z)-3-phenyl-N-(1H-1,2,4-triazol-1-ylcarbonyl)propanimidoate (1233379-32-2)

Guidance literature:

In dichloromethane; at 5 - 20 ℃; for 12h;

Reference yield:

dihydrocinnamonitrile (645-59-0) → ethyl (1Z)-3-phenyl-N-(1H-1,2,4-triazol-1-ylcarbonyl)propanimidoate (1233379-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 3 h / 0 °C

2: dichloromethane / 12 h / 5 - 20 °C

With hydrogenchloride; In 1,4-dioxane; dichloromethane;

Reference yield: 67.0%

guanazole (1455-77-2) + ethyl (1Z)-3-phenyl-N-(1H-1,2,4-triazol-1-ylcarbonyl)propanimidoate (1233379-32-2) → 2-amino-5-(2-phenylethyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(6H)-one (1233379-39-9)

Guidance literature:

In methanol; for 0.5h; regioselective reaction; Reflux;

DOI:10.1055/s-0029-1218718

upstream raw materials:

1,1'-Carbonyl-di-(1,2,4-triazole)

ethyl 3-phenylpropanimidate

dihydrocinnamonitrile

Downstream raw materials:

2-amino-5-(2-phenylethyl)[1,2,4]triazolo[1,5-a][1,3,5]triazin-7(6H)-one