N-{(1S,2S)-2-Amino-1-[(3-methoxy-benzylamino)-methyl]-3-phenyl-propyl}-4-nitro-benzenesulfonamide

Base Information

Chemical Name:N-{(1S,2S)-2-Amino-1-[(3-methoxy-benzylamino)-methyl]-3-phenyl-propyl}-4-nitro-benzenesulfonamide
CAS No.:913367-88-1
Molecular Formula:C₂₄H₂₈N₄O₅S
Molecular Weight:484.576
Hs Code.:

Synonyms:N-{(1S,2S)-2-Amino-1-[(3-methoxy-benzylamino)-methyl]-3-phenyl-propyl}-4-nitro-benzenesulfonamide

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Chemical Property of N-{(1S,2S)-2-Amino-1-[(3-methoxy-benzylamino)-methyl]-3-phenyl-propyl}-4-nitro-benzenesulfonamide

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Technology Process of N-{(1S,2S)-2-Amino-1-[(3-methoxy-benzylamino)-methyl]-3-phenyl-propyl}-4-nitro-benzenesulfonamide

There total 5 articles about N-{(1S,2S)-2-Amino-1-[(3-methoxy-benzylamino)-methyl]-3-phenyl-propyl}-4-nitro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 913367-85-8
[(1S,2S)-1-Benzyl-3-(3-methoxy-benzylamino)-2-(4-nitro-benzenesulfonylamino)-propyl]-carbamic acid benzyl ester

: 913367-88-1
N-{(1S,2S)-2-Amino-1-[(3-methoxy-benzylamino)-methyl]-3-phenyl-propyl}-4-nitro-benzenesulfonamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 3h;
DOI:10.1016/j.tetlet.2006.07.084

Reference yield:

: 913367-81-4
((S)-1-(S)-Aziridin-2-yl-2-phenyl-ethyl)-carbamic acid benzyl ester

: 913367-88-1
N-{(1S,2S)-2-Amino-1-[(3-methoxy-benzylamino)-methyl]-3-phenyl-propyl}-4-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / Et₃N / CH₂Cl₂ / 0.5 h / -20 - 10 °C

2: 76 percent / Bu₃P / acetonitrile / 2 h / 20 °C

3: 98 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C

With tributylphosphine; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2006.07.084

Reference yield:

: 913367-82-5
{(S)-1-[(S)-1-(4-Nitro-benzenesulfonyl)-aziridin-2-yl]-2-phenyl-ethyl}-carbamic acid benzyl ester

: 913367-88-1
N-{(1S,2S)-2-Amino-1-[(3-methoxy-benzylamino)-methyl]-3-phenyl-propyl}-4-nitro-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / Bu₃P / acetonitrile / 2 h / 20 °C

2: 98 percent / H₂ / Pd/C / ethanol / 3 h / 20 °C

With tributylphosphine; hydrogen; palladium on activated charcoal; In ethanol; acetonitrile;
DOI:10.1016/j.tetlet.2006.07.084