N⁸-tert-butoxycarbonyl-N¹,N⁴-methylene-N¹,N⁸-bis(4-nitrobenzyloxycarbonyl)-spermidine

Base Information

• Chemical Name: N⁸-tert-butoxycarbonyl-N¹,N⁴-methylene-N¹,N⁸-bis(4-nitrobenzyloxycarbonyl)-spermidine
• CAS No.: 141210-55-1
• Molecular Formula: C₂₉H₃₇N₅O₁₀
• Molecular Weight: 615.64

Synonyms:N⁸-tert-butoxycarbonyl-N¹,N⁴-methylene-N¹,N⁸-bis(4-nitrobenzyloxycarbonyl)-spermidine

Chemical Property of N⁸-tert-butoxycarbonyl-N¹,N⁴-methylene-N¹,N⁸-bis(4-nitrobenzyloxycarbonyl)-spermidine

Chemical Property:

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Technology Process of N⁸-tert-butoxycarbonyl-N¹,N⁴-methylene-N¹,N⁸-bis(4-nitrobenzyloxycarbonyl)-spermidine

There total 3 articles about N⁸-tert-butoxycarbonyl-N¹,N⁴-methylene-N¹,N⁸-bis(4-nitrobenzyloxycarbonyl)-spermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

di-tert-butyl dicarbonate (24424-99-5) + N1,N4-methylene-N1,N8-bis(4-nitrobenzyloxycarbonyl)-spermidine (141210-54-0) → N8-tert-butoxycarbonyl-N1,N4-methylene-N1,N8-bis(4-nitrobenzyloxycarbonyl)-spermidine (141210-55-1)

Guidance literature:

With dmap; In acetonitrile; for 55.2h; Ambient temperature;

Reference yield:

1-(4-aminobutyl)-1,2,3,4,5,6-hexahydropyrimidine (73453-98-2) → N8-tert-butoxycarbonyl-N1,N4-methylene-N1,N8-bis(4-nitrobenzyloxycarbonyl)-spermidine (141210-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / acetonitrile / 24 h / Ambient temperature

2: 72 percent / DMAP / acetonitrile / 55.2 h / Ambient temperature

With dmap; In acetonitrile;

Reference yield:

1-benzotriazolyl p-nitrobenzyl carbonate → N8-tert-butoxycarbonyl-N1,N4-methylene-N1,N8-bis(4-nitrobenzyloxycarbonyl)-spermidine (141210-55-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / acetonitrile / 24 h / Ambient temperature

2: 72 percent / DMAP / acetonitrile / 55.2 h / Ambient temperature

With dmap; In acetonitrile;

upstream raw materials:

di-tert-butyl dicarbonate

N¹,N⁴-methylene-N¹,N⁸-bis(4-nitrobenzyloxycarbonyl)-spermidine

1-(4-aminobutyl)-1,2,3,4,5,6-hexahydropyrimidine

Downstream raw materials:

N⁸-tert-butoxycarbonyl-N¹-(4-nitrobenzyloxycarbonyl)-spermidine

N⁸-tert-butoxycarbonyl-N¹,N⁴-methylene-N¹-(4-nitrobenzyloxycarbonyl)-spermidine

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