N-[3-(3-(methoxycarbonyl)-phenoxy)-1-cyanopropyl]-3-methyl-Nα-(2,2-diphenylacetyl)-L-phenylalaninamide

Base Information

Chemical Name:N-[3-(3-(methoxycarbonyl)-phenoxy)-1-cyanopropyl]-3-methyl-Nα-(2,2-diphenylacetyl)-L-phenylalaninamide
CAS No.:225121-08-4
Molecular Formula:C₃₆H₃₅N₃O₅
Molecular Weight:589.691
Hs Code.:

Synonyms:N-[3-(3-(methoxycarbonyl)-phenoxy)-1-cyanopropyl]-3-methyl-Nα-(2,2-diphenylacetyl)-L-phenylalaninamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-(3-(methoxycarbonyl)-phenoxy)-1-cyanopropyl]-3-methyl-Nα-(2,2-diphenylacetyl)-L-phenylalaninamide

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Technology Process of N-[3-(3-(methoxycarbonyl)-phenoxy)-1-cyanopropyl]-3-methyl-Nα-(2,2-diphenylacetyl)-L-phenylalaninamide

There total 11 articles about N-[3-(3-(methoxycarbonyl)-phenoxy)-1-cyanopropyl]-3-methyl-Nα-(2,2-diphenylacetyl)-L-phenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 225122-52-1
3-methyl-N-(2,2-diphenylacetyl)-L-phenylalanine

: 225122-64-5
2-amino-4-[3-(methoxycarbonyl)-phenoxy]-butyronitrile

: 225121-08-4
N-[3-(3-(methoxycarbonyl)-phenoxy)-1-cyanopropyl]-3-methyl-Nα-(2,2-diphenylacetyl)-L-phenylalaninamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

: 1871-76-7
diphenylacetic acid chloride

: 3-[3-(2-amino-3-m-tolyl-propionylamino)-3-cyano-propoxy]-benzoic acid methyl ester

: 225121-08-4
N-[3-(3-(methoxycarbonyl)-phenoxy)-1-cyanopropyl]-3-methyl-Nα-(2,2-diphenylacetyl)-L-phenylalaninamide

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm010206q

Reference yield:

: 620-13-3
1-bromomethyl-3-methyl-benzene

: 225121-08-4
N-[3-(3-(methoxycarbonyl)-phenoxy)-1-cyanopropyl]-3-methyl-Nα-(2,2-diphenylacetyl)-L-phenylalaninamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaH / dimethylformamide; hexane / 2 h / 20 °C

1.2: dimethylformamide; hexane / 2 h / 20 °C

2.1: aq. AcOH / 16 h / pH 5 / Heating

2.2: 3.55 g / Alcalase 2.4L; aq. NaHCO₃ / 2.5 h / 25 - 27 °C

3.1: N-methylmorpholine; HOAt; EDCI / CH₂Cl₂ / 20 °C

4.1: HCOOH / 6 h / 20 °C

5.1: N-methylmorpholine / CH₂Cl₂ / 2 h / 20 °C

With 4-methyl-morpholine; formic acid; 1-hydroxy-7-aza-benzotriazole; sodium hydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm010206q