2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionitrile

Base Information

Chemical Name:2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionitrile
CAS No.:147961-20-4
Molecular Formula:C₃₅H₃₂ClN₃O₂S
Molecular Weight:594.177
Hs Code.:

Synonyms:2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionitrile

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Chemical Property of 2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionitrile

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Technology Process of 2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionitrile

There total 7 articles about 2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147961-19-1
2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionamide

: 147961-20-4
2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionitrile

Guidance literature:: With pyridine; trifluoroacetic anhydride; In tetrahydrofuran; for 0.333333h; Yield given;
DOI:10.1021/jm00034a013

Reference yield:

: 155143-17-2
ethyl <1-(4-chlorobenzyl)-4-methyl-6-hydroxy-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>acetate

: 147961-20-4
2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 19 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

2: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

3: 1.) NaH, 2.) n-Bu₄NI / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, 18 h

4: dimethylaluminum amide / m-xylene; hexane; CH₂Cl₂ / 2 h / 75 °C

5: trifluoroacetic anhydride, pyridine / tetrahydrofuran / 0.33 h

With pyridine; lithium aluminium tetrahydride; dimethylaluminium amide; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; trifluoroacetic anhydride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; m-xylene; acetonitrile;
DOI:10.1021/jm00034a013

Reference yield:

: [5-Allyloxy-3-tert-butylsulfanyl-1-(4-chloro-benzyl)-1H-indol-2-yl]-acetic acid ethyl ester

: 147961-20-4
2-<2-<1-(4-chlorobenzyl)-4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-cd>indol-2-yl>ethoxy>propionitrile

Guidance literature:: Multi-step reaction with 6 steps

1: 2.) p-TSA / 1.) 1,2-dichlorobenzene, 200 deg C, 7 h, 2.) 1,2-dichlorobenzene, 150 deg C, 30 min

2: 19 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3: Cs₂CO₃ / acetonitrile; dimethylformamide / Ambient temperature

4: 1.) NaH, 2.) n-Bu₄NI / 1.) DMF, 0 deg C, 20 min, 2.) DMF, RT, 18 h

5: dimethylaluminum amide / m-xylene; hexane; CH₂Cl₂ / 2 h / 75 °C

6: trifluoroacetic anhydride, pyridine / tetrahydrofuran / 0.33 h

With pyridine; lithium aluminium tetrahydride; dimethylaluminium amide; tetra-(n-butyl)ammonium iodide; sodium hydride; caesium carbonate; toluene-4-sulfonic acid; trifluoroacetic anhydride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; m-xylene; acetonitrile;
DOI:10.1021/jm00034a013