4-chloro-7-{4-[(2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl]piperazin-1-yl}quinazoline

Base Information

Chemical Name:4-chloro-7-{4-[(2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl]piperazin-1-yl}quinazoline
CAS No.:1027345-26-1
Molecular Formula:C₂₇H₃₀Cl₂N₄
Molecular Weight:481.468
Hs Code.:

Synonyms:4-chloro-7-{4-[(2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl]piperazin-1-yl}quinazoline

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Chemical Property of 4-chloro-7-{4-[(2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl]piperazin-1-yl}quinazoline

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Technology Process of 4-chloro-7-{4-[(2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl]piperazin-1-yl}quinazoline

There total 13 articles about 4-chloro-7-{4-[(2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl]piperazin-1-yl}quinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1027345-25-0
7-[4-(4'-chloro-biphenyl-2-ylmethyl)-piperazin-1-yl]-quinazolin-4-ol

: 1027345-26-1
4-chloro-7-{4-[(2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl]piperazin-1-yl}quinazoline

Guidance literature:: With trichlorophosphate; N,N-dimethyl-formamide; In 1,2-dichloro-ethane; at 70 ℃; for 21.25h;

Reference yield: 58.0%

: 1027345-25-0
7-{4-[(2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl]piperazin-1-yl}quinazolin-4-ol

: 1027345-26-1
4-chloro-7-{4-[(2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl]piperazin-1-yl}quinazoline

Guidance literature:: 7-{4-[(2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl]piperazin-1-yl}quinazolin-4-ol; With N,N-dimethyl-formamide; trichlorophosphate; In 1,2-dichloro-ethane; at 70 ℃; for 21.25h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane;
DOI:10.1021/jm101596e

Reference yield:

: 1027345-19-2
methyl 5,5-dimethyl-2-(trifluoromethylsulfonyloxy)cyclohex-1-enecarboxylate

: 1027345-26-1
4-chloro-7-{4-[(2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl)methyl]piperazin-1-yl}quinazoline

Guidance literature:: Multi-step reaction with 5 steps

1: cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / methanol; 1,2-dimethoxyethane / 70 °C / Inert atmosphere

2: lithium aluminium tetrahydride / 2 h / -10 - 0 °C

3: phosphorus tribromide / dichloromethane / 0 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

5: N,N-dimethyl-formamide / 1,2-dichloro-ethane / 70 °C / Inert atmosphere

With lithium aluminium tetrahydride; phosphorus tribromide; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; 1,2-dimethoxyethane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;