N-(3-cyanophenyl)-3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazol-1-yl)propanethioamide

Base Information

Chemical Name:N-(3-cyanophenyl)-3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazol-1-yl)propanethioamide
CAS No.:1308761-22-9
Molecular Formula:C₂₈H₂₂N₆S
Molecular Weight:474.589
Hs Code.:

Synonyms:N-(3-cyanophenyl)-3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazol-1-yl)propanethioamide

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Chemical Property of N-(3-cyanophenyl)-3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazol-1-yl)propanethioamide

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Technology Process of N-(3-cyanophenyl)-3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazol-1-yl)propanethioamide

There total 6 articles about N-(3-cyanophenyl)-3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazol-1-yl)propanethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1308761-08-1
N-(3-cyanophenyl)-3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazol-1-yl)propanamide

: 1308761-22-9
N-(3-cyanophenyl)-3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazol-1-yl)propanethioamide

Guidance literature:: With Lawessons reagent; In 1,2-dimethoxyethane; at 85 ℃; for 12h; Sealed tube;
DOI:10.1016/j.bmc.2011.03.008

Reference yield:

: 6940-57-4
2-acetyl-6-methylpyridine

: 1308761-22-9
N-(3-cyanophenyl)-3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazol-1-yl)propanethioamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate; palladium diacetate; DavePhos / tetrahydrofuran / 14 h / 75 °C

2.1: 4 h / 90 °C

2.2: 4 h / Reflux

3.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 120 °C

4.1: Lawessons reagent / 1,2-dimethoxyethane / 12 h / 85 °C / Sealed tube

With Lawessons reagent; potassium tert-butylate; palladium diacetate; caesium carbonate; DavePhos; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.008

Reference yield:

: 476472-48-7
1-(6-methylpyridin-2-yl)-2-(quinolin-6-yl)ethanone

: 1308761-22-9
N-(3-cyanophenyl)-3-(3-(6-methylpyridin-2-yl)-4-(quinolin-6-yl)-1H-pyrazol-1-yl)propanethioamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 4 h / 90 °C

1.2: 4 h / Reflux

2.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 120 °C

3.1: Lawessons reagent / 1,2-dimethoxyethane / 12 h / 85 °C / Sealed tube

With Lawessons reagent; caesium carbonate; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.008