Tambulin

Base Information

• Chemical Name: Tambulin
• CAS No.: 571-72-2
• Molecular Formula: C18H16O7
• Molecular Weight: 344.321
• ChEMBL ID: CHEMBL478811
• DSSTox Substance ID: DTXSID40415179
• Metabolomics Workbench ID: 26234
• Nikkaji Number: J853.918I
• Wikidata: Q27108377
• Mol file: 571-72-2.mol

Synonyms:3,5-dihydroxy-7,8-dimethoxy-2-(4-methoxyphenyl) chromen-4-one;tambulin

Chemical Property of Tambulin

Chemical Property:

• Vapor Pressure: 2.18E-14mmHg at 25°C
• Boiling Point: 582°C at 760 mmHg
• Flash Point: 214°C
• Density: 1.407g/cm³
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 4
• Exact Mass: 344.08960285
• Heavy Atom Count: 25
• Complexity: 524

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=C(C(=O)C3=C(O2)C(=C(C=C3O)OC)OC)O

Technology Process of Tambulin

There total 14 articles about Tambulin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-hydroxy-4',7,8-trimethoxy-3-tosyloxyflavone (116512-10-8) → 4'-Hydroxywogonin (571-72-2)

Guidance literature:

With potassium carbonate; In methanol; for 1h; Heating;

Reference yield: 78.0%

5-hydroxy-4',7,8-trimethoxy-3-mesyloxyflavone (116512-11-9) → 4'-Hydroxywogonin (571-72-2)

Guidance literature:

With potassium carbonate; In methanol;

Reference yield:

7-hydroxy-3,4',5,8-tetramethoxyflavone (85734-53-8) → 4'-Hydroxywogonin (571-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone / Heating

2: 1.) 5percent AlBr₃, 2.) TsCl, K₂CO₃, 3.) 5percent AlBr₃ / 1.) acetonitrile, RT, 2 h, 2.) acetone, 3.) acetonitrile

With aluminum tri-bromide; potassium carbonate; p-toluenesulfonyl chloride; In acetone;

DOI:10.1016/0031-9422(88)80222-X

upstream raw materials:

3,5,7,8-tetramethoxy-2-(4-methoxyphenyl)chromen-4-one

5-hydroxy-4',7,8-trimethoxy-3-mesyloxyflavone

5-hydroxy-4',7,8-trimethoxy-3-tosyloxyflavone

7-hydroxy-3,4',5,8-tetramethoxyflavone

Refernces

• 1、 Horie, Tokunaru,Tsukayama, Masao,Kawamura, Yasuhiko,Yamamoto, Shigeo. "STUDIES OF THE SELECTIVE O-ALKYLATION AND DEALKYLATION OF FLAVONOIDS. IX. A NEW METHOD FOR SYNTHESIZING 3,5-DIHYDROXY-7,8-DIMETHOXYFLAVONES FROM 3-HYDROXY-5,7,8-TRIMETHOXYFLAVONES". . p. 4465 - 4472. Retrieved 2007/10/02.