N-[(2S)-1-[⁽¹⁸⁾F]fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

Base Information

• Chemical Name: N-[(2S)-1-[⁽¹⁸⁾F]fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine
• CAS No.: 1373348-54-9
• Molecular Formula: C₁₃H₁₆FN
• Molecular Weight: 206.261

Synonyms:N-[(2S)-1-[⁽¹⁸⁾F]fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

Chemical Property of N-[(2S)-1-[⁽¹⁸⁾F]fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

Chemical Property:

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Technology Process of N-[(2S)-1-[⁽¹⁸⁾F]fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

There total 4 articles about N-[(2S)-1-[⁽¹⁸⁾F]fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(2S)-1-fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-(2)H2)prop-2-yn-1-amine (1373348-53-8) → N-[(2S)-1-[(18)F]fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-(2)H2)prop-2-yn-1-amine (1373348-54-9)

Guidance literature:

With potassium carbonate; [2.2.2]cryptande; In dimethyl sulfoxide; at 50 - 120 ℃; for 0.333333h; sealed tube; Inert atmosphere;

Reference yield:

N-[(2R)-2-chloro-3-phenylpropyl]-N-methyl(1,1-(2)H2)prop-2-yn-1-amine (1373348-52-7) → N-[(2S)-1-[(18)F]fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-(2)H2)prop-2-yn-1-amine (1373348-54-9) + N-[(2R)-2-[(18)F]fluoro-3-phenylpropyl]-N-methyl(1,1-(2)H2)prop-2-yn-1-amine (1373348-59-4)

Guidance literature:

With potassium carbonate; [2.2.2]cryptande; [18F]fluoride ion, cyclotron produced, NCA; In dimethyl sulfoxide; acetonitrile; at 120 ℃; for 0.333333h;

Reference yield:

N-Methyl-L-phenylalanine (2566-30-5) → N-[(2S)-1-[(18)F]fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-(2)H2)prop-2-yn-1-amine (1373348-54-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -10 °C / Reflux

1.2: -40 °C

2.1: potassium carbonate / tetrahydrofuran / 20 °C

3.1: Nonafluorobutanesulfonyl fluoride; triethylamine tris(hydrogen fluoride); triethylamine / tetrahydrofuran / 24 h / 20 °C

4.1: potassium carbonate; [2.2.2]cryptande / dimethyl sulfoxide / 0.33 h / 50 - 120 °C / sealed tube; Inert atmosphere

With lithium aluminium tetrahydride; Nonafluorobutanesulfonyl fluoride; potassium carbonate; triethylamine tris(hydrogen fluoride); triethylamine; [2.2.2]cryptande; In tetrahydrofuran; dimethyl sulfoxide;

upstream raw materials:

N-Methyl-L-phenylalanine

(S)-(+)-2-(N-methylamino)-3-phenylpropanol

N-[(2S)-1-fluoro-3-phenylpropan-2-yl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

N-[(2R)-2-chloro-3-phenylpropyl]-N-methyl(1,1-⁽²⁾H₂)prop-2-yn-1-amine

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