2-chloro-4-[6-((R)-2-hydroxy-1-phenyl-ethylamino)-pyrazin-2-yl]-phenol

Base Information

Chemical Name:2-chloro-4-[6-((R)-2-hydroxy-1-phenyl-ethylamino)-pyrazin-2-yl]-phenol
CAS No.:1617545-80-8
Molecular Formula:C₁₈H₁₆ClN₃O₂
Molecular Weight:341.797
Hs Code.:

Synonyms:2-chloro-4-[6-((R)-2-hydroxy-1-phenyl-ethylamino)-pyrazin-2-yl]-phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-chloro-4-[6-((R)-2-hydroxy-1-phenyl-ethylamino)-pyrazin-2-yl]-phenol

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Technology Process of 2-chloro-4-[6-((R)-2-hydroxy-1-phenyl-ethylamino)-pyrazin-2-yl]-phenol

There total 2 articles about 2-chloro-4-[6-((R)-2-hydroxy-1-phenyl-ethylamino)-pyrazin-2-yl]-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 629657-95-0
(R)-2-(6-chloro-pyrazin-2-ylamino)-2-phenyl-ethanol

: 629658-06-6
2‐chloro‐4‐(4,4,5,5‐tetramethyl‐1,3,2‐dioxaborolan‐2‐yl)phenol

: 1617545-80-8
2-chloro-4-[6-((R)-2-hydroxy-1-phenyl-ethylamino)-pyrazin-2-yl]-phenol

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 0.666667h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 1617545-80-8
2-chloro-4-[6-((R)-2-hydroxy-1-phenyl-ethylamino)-pyrazin-2-yl]-phenol

Guidance literature:: Multi-step reaction with 2 steps

1: isopropyl alcohol / 1.5 h / 180 °C / Inert atmosphere; Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 0.67 h / 90 °C / Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; isopropyl alcohol;