5-[4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butane-1-sulfonyl]-1-phenyl-1H-tetrazole

Base Information

Chemical Name:5-[4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butane-1-sulfonyl]-1-phenyl-1H-tetrazole
CAS No.:860437-85-0
Molecular Formula:C₃₃H₄₆N₄O₄SSi₂
Molecular Weight:650.99
Hs Code.:

5-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-(<i>tert</i>-butyl-diphenyl-silanyloxy)-butane-1-sulfonyl]-1-phenyl-1<i>H</i>-tetrazole

Synonyms:5-[4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butane-1-sulfonyl]-1-phenyl-1H-tetrazole

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Chemical Property of 5-[4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butane-1-sulfonyl]-1-phenyl-1H-tetrazole

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Technology Process of 5-[4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butane-1-sulfonyl]-1-phenyl-1H-tetrazole

There total 3 articles about 5-[4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butane-1-sulfonyl]-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 860438-10-4
5-[4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butylsulfanyl]-1-phenyl-1H-tetrazole

: 860437-85-0
5-[4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butane-1-sulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: With ammonium molybdate tetrahydrate; dihydrogen peroxide; In ethanol; at 20 ℃; for 18h;
DOI:10.1021/ol0511833

Reference yield:

: 860437-83-8
4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butan-1-ol

: 860437-85-0
5-[4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butane-1-sulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / PPh₃; DIAD / tetrahydrofuran / 0 - 20 °C

2: 82 percent / Mo₇O₂₄(NH₄)6*4H₂O; aq. H₂O₂ / ethanol / 18 h / 20 °C

With ammonium molybdate tetrahydrate; di-isopropyl azodicarboxylate; dihydrogen peroxide; triphenylphosphine; In tetrahydrofuran; ethanol; 1: Mitsunobu reaction;
DOI:10.1021/ol0511833

Reference yield:

: 4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butyric acid methyl ester

: 860437-85-0
5-[4-(tert-butyl-dimethyl-silanyloxy)-3-(tert-butyl-diphenyl-silanyloxy)-butane-1-sulfonyl]-1-phenyl-1H-tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: DibalH / CH₂Cl₂; hexane / 5 h / -78 °C

1.2: 92 percent / NaBH₄ / tetrahydrofuran; methanol / 2 h / 0 °C

2.1: 92 percent / PPh₃; DIAD / tetrahydrofuran / 0 - 20 °C

3.1: 82 percent / Mo₇O₂₄(NH₄)6*4H₂O; aq. H₂O₂ / ethanol / 18 h / 20 °C

With ammonium molybdate tetrahydrate; di-isopropyl azodicarboxylate; dihydrogen peroxide; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; dichloromethane; 2.1: Mitsunobu reaction;
DOI:10.1021/ol0511833