2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate

Base Information

Chemical Name:2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate
CAS No.:1426050-47-6
Molecular Formula:C₂₁H₂₅BrF₂N₂O₄
Molecular Weight:487.341
Hs Code.:

Synonyms:2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate

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Chemical Property of 2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate

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Technology Process of 2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate

There total 11 articles about 2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426050-46-5
2-bromo-2-(4-bromo-2,6-difluorophenyl)ethyl acetate

: 1375107-47-3
4-cyclopropyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one hydrochloride

: 1426050-47-6
2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1375107-45-1
1,1-dimethylethyl-4-{[(chloroacetyl)(cyclopropyl)amino]methyl}-4-hydroxy-1-piperidine carboxylate

: 1426050-47-6
2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide / tetrahydrofuran; water

2: hydrogenchloride; ethanol / 1,4-dioxane / 20 °C / Cooling with ice

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; ethanol; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1375107-46-2
1,1-dimethylethyl 4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

: 1426050-47-6
2-(4-bromo-2,6-difluorophenyl)-2-(4-cyclopropyl-3-oxo-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; ethanol / 1,4-dioxane / 20 °C / Cooling with ice

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; ethanol; potassium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;